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UniProtKB/Swiss-Prot entry P00400

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name COX1_DROYA
Primary accession number P00400
Secondary accession numbers None
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on July 21, 1986 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 75)
Name and origin of the protein
Protein name Cytochrome c oxidase subunit 1
Synonyms EC 1.9.3.1
Cytochrome c oxidase polypeptide I
Gene name
Name: mt:CoI
Synonyms: CoI
From
Drosophila yakuba (Fruit fly) [TaxID: 7245] 
Encoded on Mitochondrion.
Taxonomy Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=2317.6 Ivory Coast;
DOI=10.1007/BF02099755; PubMed=3001325 [NCBI, ExPASy, EBI, Israel, Japan]
Clary D.O., Wolstenholme D.R.;
"The mitochondrial DNA molecular of Drosophila yakuba: nucleotide sequence, gene organization, and genetic code.";
J. Mol. Evol. 22:252-271(1985).
[2]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
DOI=10.1093/nar/11.19.6859; PubMed=6314262 [NCBI, ExPASy, EBI, Israel, Japan]
Clary D.O., Wolstenholme D.R.;
"Genes for cytochrome c oxidase subunit I, URF2, and three tRNAs in Drosophila mitochondrial DNA.";
Nucleic Acids Res. 11:6859-6872(1983).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X03240; CAC14066.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A93488; ODFF1Y.
3D structure databases
HSSP P00396; 2OCC. [HSSP ENTRY / PDB]
SMR P00400; 4-506.
ModBase P00400.
Organism-specific databases
FlyBase FBgn0013179; Dyak\mt:CoI.
Ontologies
GO
GO:0016021; Cellular component: integral to membrane (inferred from electronic annotation from InterPro).
GO:0005746; Cellular component: mitochondrial respiratory chain (inferred from electronic annotation from UniProtKB-KW).
GO:0005507; Molecular function: copper ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0004129; Molecular function: cytochrome-c oxidase activity (inferred from electronic annotation from EC).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0020037; Molecular function: heme binding (inferred from electronic annotation from InterPro).
GO:0005506; Molecular function: iron ion binding (inferred from electronic annotation from InterPro).
GO:0009060; Biological process: aerobic respiration (inferred from electronic annotation from InterPro).
GO:0022900; Biological process: electron transport chain (inferred from electronic annotation from UniProtKB-KW).
GO:0006810; Biological process: transport (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR000883; COX1.
Graphical view of domain structure.
Gene3D G3DSA:1.20.210.10; COX1; 1.
PANTHER PTHR10422; COX1; 1.
Pfam PF00115; COX1; 1.
Pfam graphical view of domain structure.
PRINTS PR01165; CYCOXIDASEI.
PROSITE PS50855; COX1; 1.
PS00077; COX1_CUB; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet P00400.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Copper; Electron transport; Heme; Iron; Membrane; Metal-binding; Mitochondrion; Mitochondrion inner membrane; Oxidoreductase; Respiratory chain; Transmembrane; Transport.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   512  512     Cytochrome c oxidase subunit 1. PRO_0000183329
TRANSMEM   16    36  21     Potential. 
TRANSMEM   55    75  21     Potential. 
TRANSMEM   101   121  21     Potential. 
TRANSMEM   144   164  21     Potential. 
TRANSMEM   182   202  21     Potential. 
TRANSMEM   233   253  21     Potential. 
TRANSMEM   267   287  21     Potential. 
TRANSMEM   304   324  21     Potential. 
TRANSMEM   337   357  21     Potential. 
TRANSMEM   379   399  21     Potential. 
TRANSMEM   413   433  21     Potential. 
TRANSMEM   451   471  21     Potential. 
METAL   60    60        Iron (heme A axial ligand) (Probable). 
METAL   239   239        Copper B (Probable). 
METAL   243   243        Copper B (Probable). 
METAL   289   289        Copper B (Probable). 
METAL   290   290        Copper B (Probable). 
METAL   375   375        Iron (heme A3 axial ligand) (Probable). 
METAL   377   377        Iron (heme A axial ligand) (Probable). 
CROSSLNK   239   243        1'-histidyl-3'-tyrosine (His-Tyr) (By similarity). 
Sequence information
Length: 512 AA [This is the length of the unprocessed precursor] Molecular weight: 56526 Da [This is the MW of the unprocessed precursor] CRC64: 5B63A3F05FDE227C [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSRQWLFSTN HKDIGTLYFI FGAWAGMVGT SLSILIRAEL GHPGALIGDD QIYNVIVTAH 

        70         80         90        100        110        120 
AFIMIFFMVM PIMIGGFGNW LVPLMLGAPD MAFPRMNNMS FWLLPPALSL LLVSSMVENG 

       130        140        150        160        170        180 
AGTGWTVYPP LSSGIAHGGA SVDLAIFSLH LAGISSILGA VNFITTVINM RSTGITLDRM 

       190        200        210        220        230        240 
PLFVWSVVIT ALLLLLSLPV LAGAITMLLT DRNLNTSFFD PAGGGDPILY QHLFWFFGHP 

       250        260        270        280        290        300 
EVYILILPGF GMISHIISQE SGKKETFGSL GMIYAMLAIG LLGFIVWAHH MFTVGMDVDT 

       310        320        330        340        350        360 
RAYFTSATMI IAVPTGIKIF SWLATLHGTQ LSYSPAILWA LGFVFLFTVG GLTGVVLANS 

       370        380        390        400        410        420 
SVDIILHDTY YVVAHFHYVL SMGAVFAIMA GFIHWYPLFT GLTLNNKWLK SQFIIMFIGV 

       430        440        450        460        470        480 
NLTFFPQHFL GLAGMPRRYS DYPDAYTTWN VVSTIGSTIS LLGILFFFYI IWESLVSQRQ 

       490        500        510 
VIYPIQLNSS IEWYQNTPPA EHSYSELPLL TN
P00400 in FASTA format

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