ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry P00340

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name LDHA_CHICK
Primary accession number P00340
Secondary accession numbers None
Integrated into Swiss-Prot on July 21, 1986
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 68)
Name and origin of the protein
Protein name L-lactate dehydrogenase A chain
Synonyms LDH-A
EC 1.1.1.27
Gene name
Name: LDHA
From
Gallus gallus (Chicken) [TaxID: 9031] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1093/nar/18.21.6432; PubMed=2243792 [NCBI, ExPASy, EBI, Israel, Japan]
Hirota Y., Katsumata A., Takeya T.;
"Nucleotide and deduced amino acid sequences of chicken lactate dehydrogenase-A.";
Nucleic Acids Res. 18:6432-6432(1990).
[2]
 PROTEIN SEQUENCE OF 2-332.
Torff H.-J., Becker D., Schwarzwalder J.;
(In) Sund H. (eds.); Pyridine nucleotide dependent dehydrogenases, pp.31-42, Walter de Gruyter, Berlin (1977).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
X53828; CAA37824.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR A00349; DECHLM.
S12151; S12151.
RefSeq NP_990615.1; -.
UniGene Gga.4398
3D structure databases
HSSP P00338; 1I10. [HSSP ENTRY / PDB]
SMR P00340; 2-332.
ModBase P00340.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
ProtoNet P00340.
Genome annotation databases
Ensembl ENSGALG00000006300; Gallus gallus. [Contig view]
GeneID 396221; -.
KEGG gga:396221; -.
Phylogenomic databases
HOGENOM P00340; -.
HOVERGEN P00340; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Direct protein sequencing; Glycolysis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed. 
CHAIN   2   332  331     L-lactate dehydrogenase A chain. PRO_0000168420
NP_BIND   29    57  29     NAD (By similarity). 
ACT_SITE   193   193        Proton acceptor (By similarity). 
BINDING   99    99        NAD (By similarity). 
BINDING   106   106        Substrate (By similarity). 
BINDING   138   138        NAD or substrate (By similarity). 
BINDING   169   169        Substrate (By similarity). 
BINDING   248   248        Substrate (By similarity). 
CONFLICT   63    63        L -> M (in Ref. 2; AA sequence). 
CONFLICT   78    78        I -> T (in Ref. 2; AA sequence). 
CONFLICT   192   192        E -> Q (in Ref. 2; AA sequence). 
Sequence information
Length: 332 AA [This is the length of the unprocessed precursor] Molecular weight: 36514 Da [This is the MW of the unprocessed precursor] CRC64: 5ED8279CFAD7B62B [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSLKDHLIHN VHKEEHAHAH NKISVVGVGA VGMACAISIL MKDLADELTL VDVVEDKLKG 

        70         80         90        100        110        120 
EMLDLQHGSL FLKTPKIISG KDYSVTAHSK LVIVTAGARQ QEGESRLNLV QRNVNIFKFI 

       130        140        150        160        170        180 
IPNVVKYSPD CKLLIVSNPV DILTYVAWKI SGFPKHRVIG SGCNLDSARF RHLMGERLGI 

       190        200        210        220        230        240 
HPLSCHGWIV GEHGDSSVPV WSGVNVAGVS LKALHPDMGT DADKEHWKEV HKQVVDSAYE 

       250        260        270        280        290        300 
VIKLKGYTSW AIGLSVADLA ETIMKNLRRV HPISTAVKGM HGIKDDVFLS VPCVLGSSGI 

       310        320        330 
TDVVKMILKP DEEEKIKKSA DTLWGIQKEL QF
P00340 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by ch flag SIB Switzerland Mirror sites: Australia Brazil Canada China Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!