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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
PubMed=3902818 [NCBI, ExPASy, EBI, Israel, Japan]
Tukey R.H.,
Okino S.,
Barnes H.J.,
Griffin K.J.,
Johnson E.F.;
"Multiple gene-like sequences related to the rabbit hepatic progesterone 21-hydroxylase cytochrome P-450 1.";
J. Biol. Chem. 260:13347-13354(1985).
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[2]
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SEQUENCE REVISION TO 252.
Tukey R.H.;
Submitted (FEB-1986) to the EMBL/GenBank/DDBJ databases.
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=III/J;
TISSUE=Liver;
PubMed=2387874 [NCBI, ExPASy, EBI, Israel, Japan]
Pendurthi U.R.,
Lamb J.G.,
Nguyen N.,
Johnson E.F.,
Tukey R.H.;
"Characterization of the CYP2C5 gene in 21L III/J rabbits. Allelic variation affects the expression of P450IIC5.";
J. Biol. Chem. 265:14662-14668(1990).
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[4]
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X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
DOI=10.1016/S1097-2765(00)80408-6; PubMed=10678174 [NCBI, ExPASy, EBI, Israel, Japan]
Williams P.A.,
Cosme J.,
Sridhar V.,
Johnson E.F.,
McRee D.E.;
"Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity.";
Mol. Cell 5:121-131(2000).
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[5]
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X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) IN COMPLEX WITH SUBSTRATE ANALOG.
DOI=10.1021/bi0273922; PubMed=12767218 [NCBI, ExPASy, EBI, Israel, Japan]
Wester M.R.,
Johnson E.F.,
Marques-Soares C.,
Dansette P.M.,
Mansuy D.,
Stout C.D.;
"Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes.";
Biochemistry 42:6370-6379(2003).
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- FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
- CATALYTIC ACTIVITY: RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
- COFACTOR: Heme group.
- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane (By similarity). Microsome membrane (By similarity).
- INDUCTION: P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
- MISCELLANEOUS: This protein differs from other forms of cytochrome P450 in that it catalyzes the 21-hydroxylation of progesterone, resulting in the formation of deoxycorticosterone.
- SIMILARITY: Belongs to the cytochrome P450 family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 487 AA [This is the length of the unprocessed precursor] |
Molecular weight: 55275 Da [This is the MW of the unprocessed precursor] |
CRC64: ED67B2E255DF5EA0 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MDPVVVLVLG LCCLLLLSIW KQNSGRGKLP PGPTPFPIIG NILQIDAKDI SKSLTKFSEC
70 80 90 100 110 120
YGPVFTVYLG MKPTVVLHGY EAVKEALVDL GEEFAGRGSV PILEKVSKGL GIAFSNAKTW
130 140 150 160 170 180
KEMRRFSLMT LRNFGMGKRS IEDRIQEEAR CLVEELRKTN ASPCDPTFIL GCAPCNVICS
190 200 210 220 230 240
VIFHNRFDYK DEEFLKLMES LNENVRILSS PWLQVYNNFP ALLDYFPGIH KTLLKNADYI
250 260 270 280 290 300
KNFIMEKVKE HQKLLDVNNP RDFIDCFLIK MEQENNLEFT LESLVIAVSD LFGAGTETTS
310 320 330 340 350 360
TTLRYSLLLL LKHPEVAARV QEEIERVIGR HRSPCMQDRS RMPYTDAVIH EIQRFIDLLP
370 380 390 400 410 420
TNLPHAVTRD VRFRNYFIPK GTDIITSLTS VLHDEKAFPN PKVFDPGHFL DESGNFKKSD
430 440 450 460 470 480
YFMPFSAGKR MCVGEGLARM ELFLFLTSIL QNFKLQSLVE PKDLDITAVV NGFVSVPPSY
QLCFIPI
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P00179 in FASTA format |
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