ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry O95932


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name TGM3L_HUMAN
Primary accession number O95932
Secondary accession numbers Q5JXU4 Q5JXU5 Q719M2 Q719M3 Q9Y4U8
Integrated into Swiss-Prot on May 10, 2002
Sequence was last modified on August 16, 2005 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 73)
Name and origin of the protein
Protein name Protein-glutamine gamma-glutamyltransferase 6
Synonyms EC 2.3.2.13
Transglutaminase-3-like
TGase-3-like
Transglutaminase Y
Gene name
Name: TGM6
Synonyms: TGM3L
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), AND VARIANT VAL-58.
TISSUE=Lung;
Thomas H., Aeschlimann D.;
"A novel transglutaminase expressed in the nervous system.";
Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1038/414865a; PubMed=11780052 [NCBI, ExPASy, EBI, Israel, Japan]
Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
"The DNA sequence and comparative analysis of human chromosome 20.";
Nature 414:865-871(2001).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF540969; AAQ10751.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF540970; AAQ10752.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL049650; CAI22576.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL031678; CAI22576.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL049650; CAI22577.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL031678; CAI22577.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL031678; CAI22900.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL049650; CAI22900.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL031678; CAI22901.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AL049650; CAI22901.1; JOINED; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_945345.2; -.
UniGene Hs.452039
3D structure databases
HSSP Q08188; 1L9M. [HSSP ENTRY / PDB]
ModBase O95932.
Organism-specific databases
HGNC HGNC:16255; TGM6.
GenAtlas TGM6.
PharmGKB PA38098; -.
GeneCards O95932.
Gene expression databases
ArrayExpress O95932; -.
CleanEx HS_TGM6; -.
GermOnline ENSG00000166948; Homo sapiens.
Ontologies
GO
GO:0008415; Molecular function: acyltransferase activity (inferred from electronic annotation from UniProtKB-KW).
GO:0005509; Molecular function: calcium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0003810; Molecular function: protein-glutamine gamma-glutamyltransferase activity (inferred from electronic annotation from InterPro).
GO:0018149; Biological process: peptide cross-linking (inferred from electronic annotation from InterPro).
QuickGo view.
Family and domain databases
InterPro IPR013783; Ig-like_fold.
IPR008958; Transglutaminase_C.
IPR013808; Transglutaminase_CS.
IPR001102; Transglutaminase_N.
IPR002931; Trnsglumase_like.
Graphical view of domain structure.
Gene3D G3DSA:2.60.40.10; Ig-like_fold; 3.
Pfam PF00927; Transglut_C; 2.
PF01841; Transglut_core; 1.
PF00868; Transglut_N; 1.
Pfam graphical view of domain structure.
SMART SM00460; TGc; 1.
SMART graphical view of domain structure.
PROSITE PS00547; TRANSGLUTAMINASES; 1.
ProtoNet O95932.
Genome annotation databases
Ensembl ENSG00000166948; Homo sapiens. [Contig view]
GeneID 343641; -.
KEGG hsa:343641; -.
NMPDR fig|9606.3.peg.19725; -.
Phylogenomic databases
HOGENOM O95932; -.
HOVERGEN O95932; -.
Other
DrugBank DB00130; L-Glutamine.
NextBio 98594; -.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Acyltransferase; Alternative splicing; Calcium; Metal-binding; Polymorphism; Transferase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   706  706     Protein-glutamine gamma-glutamyltransferase 6. PRO_0000213715
ACT_SITE   274   274        By similarity. 
ACT_SITE   333   333        By similarity. 
ACT_SITE   356   356        By similarity. 
METAL   396   396        Calcium (By similarity). 
METAL   398   398        Calcium (By similarity). 
METAL   445   445        Calcium (By similarity). 
METAL   450   450        Calcium (By similarity). 
VAR_SEQ   612   625        VLGPAMVGVAVTVE -> RAYPGASGEGLSPV (in isoform 2). VSP_015103
VAR_SEQ   626   706        Missing (in isoform 2). VSP_015104
VARIANT   58    58  1     M -> V (in dbSNP:rs2076405 [NCBI]). VAR_013250 
Sequence information
Length: 706 AA [This is the length of the unprocessed precursor] Molecular weight: 79312 Da [This is the MW of the unprocessed precursor] CRC64: 97BBE2043C5FF834 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MAGIRVTKVD WQRSRNGAAH HTQEYPCPEL VVRRGQSFSL TLELSRALDC EEILIFTMET 

        70         80         90        100        110        120 
GPRASEALHT KAVFQTSELE RGEGWTAARE AQMEKTLTVS LASPPSAVIG RYLLSIRLSS 

       130        140        150        160        170        180 
HRKHSNRRLG EFVLLFNPWC AEDDVFLASE EERQEYVLSD SGIIFRGVEK HIRAQGWNYG 

       190        200        210        220        230        240 
QFEEDILNIC LSILDRSPGH QNNPATDVSC RHNPIYVTRV ISAMVNSNND RGVVQGQWQG 

       250        260        270        280        290        300 
KYGGGTSPLH WRGSVAILQK WLKGRYKPVK YGQCWVFAGV LCTVLRCLGI ATRVVSNFNS 

       310        320        330        340        350        360 
AHDTDQNLSV DKYVDSFGRT LEDLTEDSMW NFHVWNESWF ARQDLGPSYN GWQVLDATPQ 

       370        380        390        400        410        420 
EESEGVFRCG PASVTAIREG DVHLAHDGPF VFAEVNADYI TWLWHEDESR ERVYSNTKKI 

       430        440        450        460        470        480 
GRCISTKAVG SDSRVDITDL YKYPEGSRKE RQVYSKAVNR LFGVEASGRR IWIRRAGGRC 

       490        500        510        520        530        540 
LWRDDLLEPA TKPSIAGKFK VLEPPMLGHD LRLALCLANL TSRAQRVRVN LSGATILYTR 

       550        560        570        580        590        600 
KPVAEILHES HAVRLGPQEE KRIPITISYS KYKEDLTEDK KILLAAMCLV TKGEKLLVEK 

       610        620        630        640        650        660 
DITLEDFITI KVLGPAMVGV AVTVEVTVVN PLIERVKDCA LMVEGSGLLQ EQLSIDVPTL 

       670        680        690        700 
EPQERASVQF DITPSKSGPR QLQVDLVSPH FPDIKGFVIV HVATAK 

O95932 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!