ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry O95750


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name FGF19_HUMAN
Primary accession number O95750
Secondary accession numbers None
Integrated into Swiss-Prot on December 1, 2000
Sequence was last modified on May 1, 1999 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 83)
Name and origin of the protein
Protein name Fibroblast growth factor 19 [Precursor]
Synonym FGF-19
Gene name
Name: FGF19
ORFNames: UNQ334/PRO533
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 1: Evidence at protein level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Brain;
DOI=10.1016/S0167-4781(98)00255-3; PubMed=9931477 [NCBI, ExPASy, EBI, Israel, Japan]
Nishimura T., Utsunomiya Y., Hoshikawa M., Ohuchi H., Itoh N.;
"Structure and expression of a novel human FGF, FGF-19, expressed in the fetal brain.";
Biochim. Biophys. Acta 1444:148-151(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND RECEPTOR SPECIFICITY.
DOI=10.1006/cyto.1999.0485; PubMed=10525310 [NCBI, ExPASy, EBI, Israel, Japan]
Xie M.-H., Holcomb I., Deuel B., Dowd P., Huang A., Vagts A., Foster J., Liang J., Brush J., Gu Q., Hillan K., Goddard A., Gurney A.L.;
"FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4.";
Cytokine 11:729-735(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Colon;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
PROTEIN SEQUENCE OF 25-39.
DOI=10.1110/ps.04682504; PubMed=15340161 [NCBI, ExPASy, EBI, Israel, Japan]
Zhang Z., Henzel W.J.;
"Signal peptide prediction based on analysis of experimentally verified cleavage sites.";
Protein Sci. 13:2819-2824(2004).
[7]
X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 39-196, AND DISULFIDE BONDS.
DOI=10.1021/bi035320k; PubMed=14730967 [NCBI, ExPASy, EBI, Israel, Japan]
Harmer N.J., Pellegrini L., Chirgadze D., Fernandez-Recio J., Blundell T.L.;
"The crystal structure of fibroblast growth factor (FGF) 19 reveals novel features of the FGF family and offers a structural basis for its unusual receptor affinity.";
Biochemistry 43:629-640(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB018122; BAA75500.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF110400; AAD45973.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358302; AAQ88669.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT006729; AAP35375.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC017664; AAH17664.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_005108.1; -.
UniGene Hs.249200
3D structure databases
PDB
1PWA; X-ray; 1.30 A; A=39-196.[ExPASy / RCSB / EBI]
2P23; X-ray; 1.80 A; A/B=23-216.[ExPASy / RCSB / EBI]
Detailed list of linked structures.
PDBsum 1PWA; -.
2P23; -.
ModBase O95750.
Protein-protein interaction databases
DIP DIP:6039N; -.
Enzyme and pathway databases
Reactome REACT_9470; Signaling by FGFR.
Organism-specific databases
H-InvDB HIX0009891; -.
HGNC HGNC:3675; FGF19.
GenAtlas FGF19.
MIM 603891; gene. [NCBI / EBI]
PharmGKB PA28114; -.
GeneCards O95750.
Gene expression databases
ArrayExpress O95750; -.
CleanEx HS_FGF19; -.
GermOnline ENSG00000162344; Homo sapiens.
Ontologies
GO
GO:0005576; Cellular component: extracellular region (inferred from electronic annotation from UniProtKB-KW).
GO:0008083; Molecular function: growth factor activity (inferred from electronic annotation from InterPro).
GO:0007399; Biological process: nervous system development (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR017338; Fibroblast_GF_15/19/21.
IPR002209; GF_heparin_bd.
IPR002348; IL1_HBGF.
Graphical view of domain structure.
PANTHER PTHR11486; IL1_HBGF; 1.
Pfam PF00167; FGF; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF037961; FGF-19_FGF-21; 1.
PRINTS PR00263; HBGFFGF.
PR00262; IL1HBGF.
ProDom PD000831; IL1_HBGF; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00442; FGF; 1.
SMART graphical view of domain structure.
PROSITE PS00247; HBGF_FGF; 1.
ProtoNet O95750.
Genome annotation databases
Ensembl ENSG00000162344; Homo sapiens. [Contig view]
GeneID 9965; -.
KEGG hsa:9965; -.
Phylogenomic databases
HOGENOM O95750; -.
HOVERGEN O95750; -.
Other
NextBio 37606; -.
SOURCE FGF19; Homo sapiens.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
3D-structure; Direct protein sequencing; Growth factor; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    24  24      
CHAIN   25   216  192     Fibroblast growth factor 19. PRO_0000008993
DISULFID   58    70         
DISULFID   102   120         
STRAND   42    49  8      
STRAND   58    62  5      
STRAND   66    73  8      
HELIX   76    78  3      
STRAND   80    86  7      
STRAND   89    94  6      
TURN   95    97  3      
STRAND   100   103  4      
HELIX   105   107  3      
STRAND   109   114  6      
HELIX   117   120  4      
STRAND   121   126  6      
STRAND   132   136  5      
TURN   137   140  4      
STRAND   165   168  4      
Sequence information
Length: 216 AA [This is the length of the unprocessed precursor] Molecular weight: 24003 Da [This is the MW of the unprocessed precursor] CRC64: E0BCBC9C220F9832 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MRSGCVVVHV WILAGLWLAV AGRPLAFSDA GPHVHYGWGD PIRLRHLYTS GPHGLSSCFL 

        70         80         90        100        110        120 
RIRADGVVDC ARGQSAHSLL EIKAVALRTV AIKGVHSVRY LCMGADGKMQ GLLQYSEEDC 

       130        140        150        160        170        180 
AFEEEIRPDG YNVYRSEKHR LPVSLSSAKQ RQLYKNRGFL PLSHFLPMLP MVPEEPEDLR 

       190        200        210 
GHLESDMFSS PLETDSMDPF GLVTGLEAVR SPSFEK 

O95750 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ch flag SIB Switzerland Mirror sites: Australia  Brazil  Canada  China  Korea
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!