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[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Brain;
PubMed=10233149 [NCBI, ExPASy, EBI, Israel, Japan]
Yuan W.,
Stromhaug P.E.,
Dunn W.A. Jr.;
"Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein.";
Mol. Biol. Cell 10:1353-1366(1999).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
TISSUE=Placenta;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 179-703 (ISOFORM 1).
TISSUE=Testis;
The German cDNA consortium;
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
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[4]
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TISSUE SPECIFICITY.
DOI=10.1006/bbrc.2002.6645; PubMed=11890701 [NCBI, ExPASy, EBI, Israel, Japan]
Tanida I.,
Tanida-Miyake E.,
Nishitani T.,
Komatsu M.,
Yamazaki H.,
Ueno T.,
Kominami E.;
"Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs.";
Biochem. Biophys. Res. Commun. 292:256-262(2002).
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[5]
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INTERACTION WITH ATG3 AND ATG12.
TISSUE=Brain;
DOI=10.1074/jbc.M200385200; PubMed=11825910 [NCBI, ExPASy, EBI, Israel, Japan]
Tanida I.,
Tanida-Miyake E.,
Komatsu M.,
Ueno T.,
Kominami E.;
"Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.";
J. Biol. Chem. 277:13739-13744(2002).
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- FUNCTION: Functions as an E1 enzyme essential for multisubstrates such as GABARAPL1 and ATG12. Forms intermediate conjugates with GABARAPL1 (GABARAPL2, GABARAP or MAP1ALC3). Formation of the final GABARAPL1-PE conjugate is essential for autophagy (By similarity).
- SUBUNIT: Homodimer (By similarity). Interacts with ATG3 and ATG12. The complex, composed of ATG3 and ATG7, plays a role in the conjugation of ATG12 to ATG5.
- SUBCELLULAR LOCATION: Cytoplasm (Probable).
- ALTERNATIVE PRODUCTS:
2 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Isoform ID | O95352-2 |
| Features which should be applied to build the isoform sequence: VSP_013205. |
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- TISSUE SPECIFICITY: Widely expressed, especially in kidney, liver, lymph nodes and bone marrow.
- DOMAIN: The C-terminal part of the protein is essential for the dimerization and interaction with ATG3 and ATG12 (By similarity).
- SIMILARITY: Belongs to the ATG7 family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 703 AA [This is the length of the unprocessed precursor] |
Molecular weight: 77960 Da [This is the MW of the unprocessed precursor] |
CRC64: ABBD1A29A6C58356 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MAAATGDPGL SKLQFAPFSS ALDVGFWHEL TQKKLNEYRL DEAPKDIKGY YYNGDSAGLP
70 80 90 100 110 120
ARLTLEFSAF DMSAPTPARC CPAIGTLYNT NTLESFKTAD KKLLLEQAAN EIWESIKSGT
130 140 150 160 170 180
ALENPVLLNK FLLLTFADLK KYHFYYWFCY PALCLPESLP LIQGPVGLDQ RFSLKQIEAL
190 200 210 220 230 240
ECAYDNLCQT EGVTALPYFL IKYDENMVLV SLLKHYSDFF QGQRTKITIG VYDPCNLAQY
250 260 270 280 290 300
PGWPLRNFLV LAAHRWSSSF QSVEVVCFRD RTMQGARDVA HSIIFEVKLP EMAFSPDCPK
310 320 330 340 350 360
AVGWEKNQKG GMGPRMVNLS ECMDPKRLAE SSVDLNLKLM CWRLVPTLDL DKVVSVKCLL
370 380 390 400 410 420
LGAGTLGCNV ARTLMGWGVR HITFVDNAKI SYSNPVRQPL YEFEDCLGGG KPKALAAADR
430 440 450 460 470 480
LQKIFPGVNA RGFNMSIPMP GHPVNFSSVT LEQARRDVEQ LEQLIESHDV VFLLMDTRES
490 500 510 520 530 540
RWLPAVIAAS KRKLVINAAL GFDTFVVMRH GLKKPKQQGA GDLCPNHPVA SADLLGSSLF
550 560 570 580 590 600
ANIPGYKLGC YFCNDVVAPG DSTRDRTLDQ QCTVSRPGLA VIAGALAVEL MVSVLQHPEG
610 620 630 640 650 660
GYAIASSSDD RMNEPPTSLG LVPHQIRGFL SRFDNVLPVS LAFDKCTACS SKVLDQYERE
670 680 690 700
GFNFLAKVFN SSHSFLEDLT GLTLLHQETQ AAEIWDMSDD ETI
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O95352 in FASTA format |
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