ID GBRAP_HUMAN Reviewed; 117 AA. AC O95166; DT 01-MAR-2004, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-1999, sequence version 1. DT 25-NOV-2008, entry version 62. DE RecName: Full=Gamma-aminobutyric acid receptor-associated protein; DE AltName: Full=GABA(A) receptor-associated protein; DE AltName: Full=MM46; GN Name=GABARAP; Synonyms=FLC3B; ORFNames=HT004; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INTERACTION WITH RP GABRG2 AND BETA-TUBULIN. RC TISSUE=Brain; RX MEDLINE=99107373; PubMed=9892355; DOI=10.1038/16264; RA Wang H., Bedford F.K., Brandon N.J., Moss S.J., Olsen R.W.; RT "GABA(A)-receptor-associated protein links GABA(A) receptors and the RT cytoskeleton."; RL Nature 397:69-72(1999). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INTERACTION WITH RP ULK1. RC TISSUE=Frontal cortex; RX MEDLINE=21066693; PubMed=11146101; DOI=10.1016/S0169-328X(00)00218-7; RA Okazaki N., Yan J., Yuasa S., Ueno T., Kominami E., Masuho Y., RA Koga H., Muramatsu M.-A.; RT "Interaction of the Unc-51-like kinase and microtubule-associated RT protein light chain 3 related proteins in the brain: possible role of RT vesicular transport in axonal elongation."; RL Brain Res. Mol. Brain Res. 85:1-12(2000). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Iijima M., Mitsui Y.; RL Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Ye M., Fu G., Wu J., Zhou J., Zhang Q., Shen Y., Kan L., He K., Gu B., RA Chen S., Mao M., Chen Z.; RL Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Hypothalamus; RX MEDLINE=20402571; PubMed=10931946; DOI=10.1073/pnas.160270997; RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., RA Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., RA Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., RA Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.; RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal RT axis and full-length cDNA cloning."; RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000). RN [6] RP X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS), AND INTERACTION WITH GABRG2; RP TUBULIN ALPHA AND TUBULIN BETA. RX MEDLINE=21826407; PubMed=11729197; DOI=10.1074/jbc.M109753200; RA Knight D., Harris R., McAlister M.S.B., Phelan J.P., Geddes S., RA Moss S.J., Driscoll P.C., Keep N.H.; RT "The X-ray crystal structure and putative ligand-derived peptide RT binding properties of gamma-aminobutyric acid receptor type A RT receptor-associated protein."; RL J. Biol. Chem. 277:5556-5561(2002). RN [7] RP STRUCTURE BY NMR. RX MEDLINE=21950801; PubMed=11875056; DOI=10.1074/jbc.C200050200; RA Stangler T., Mayr L.M., Willbold D.; RT "Solution structure of human GABA(A) receptor-associated protein RT GABARAP: implications for biolgoical funcrion and its regulation."; RL J. Biol. Chem. 277:13363-13366(2002). RN [8] RP STRUCTURE BY NMR. RX MEDLINE=21882795; PubMed=11885988; DOI=10.1023/A:1013884402033; RA Kouno T., Miura K., Kanematsu T., Shirakawa M., Hirata M., Kawano K.; RT "1H, 13C and '5N resonance assignments of GABARAP, GABAA receptor RT associated protein."; RL J. Biomol. NMR 22:97-98(2002). CC -!- FUNCTION: May play a role in intracellular transport of GABA(A) CC receptors and its interaction with the cytoskeleton (By CC similarity). CC -!- SUBUNIT: Interacts with GPHN and NSF (By similarity). Interacts CC with GABRG2, beta-tubulin and ULK1. CC -!- INTERACTION: CC O75385:ULK1; NbExp=1; IntAct=EBI-712001, EBI-908831; CC -!- SUBCELLULAR LOCATION: Intracytoplasmic membrane (By similarity). CC Cytoplasm, cytoskeleton (By similarity). Golgi apparatus membrane CC (By similarity). Note=Largely associated with intracellular CC membrane structures including the Golgi apparatus and post- CC synaptic cisternae. Colocalizes with microtubules (By similarity). CC -!- TISSUE SPECIFICITY: Heart, brain, placenta, liver, skeletal CC muscle, kidney and pancreas. CC -!- SIMILARITY: Belongs to the MAP1 LC3 family. CC ----------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution-NoDerivs License CC ----------------------------------------------------------------------- DR EMBL; AF161586; AAD47641.1; -; mRNA. DR EMBL; AB030711; BAB21549.1; -; mRNA. DR EMBL; AF044671; AAD02337.1; -; mRNA. DR EMBL; AF067171; AAD32455.1; -; mRNA. DR EMBL; AF183425; AAG09694.1; -; mRNA. DR RefSeq; NP_009209.1; -. DR UniGene; Hs.647421; -. DR PDB; 1GNU; X-ray; 1.75 A; A=1-117. DR PDB; 1KLV; NMR; -; A=1-117. DR PDB; 1KM7; NMR; -; A=1-117. DR PDB; 1KOT; NMR; -; A=1-117. DR PDB; 3D32; X-ray; 1.30 A; A/B=1-117. DR PDBsum; 1GNU; -. DR PDBsum; 1KLV; -. DR PDBsum; 1KM7; -. DR PDBsum; 1KOT; -. DR PDBsum; 3D32; -. DR IntAct; O95166; -. DR PhosphoSite; O95166; -. DR Ensembl; ENSG00000170296; Homo sapiens. DR GeneID; 11337; -. DR KEGG; hsa:11337; -. DR H-InvDB; HIX0013108; -. DR HGNC; HGNC:4067; GABARAP. DR MIM; 605125; gene. DR PharmGKB; PA28480; -. DR HOGENOM; O95166; -. DR HOVERGEN; O95166; -. DR LinkHub; O95166; -. DR NextBio; 43075; -. DR ArrayExpress; O95166; -. DR CleanEx; HS_GABARAP; -. DR GermOnline; ENSG00000170296; Homo sapiens. DR GO; GO:0000421; C:autophagic vacuole membrane; IDA:UniProtKB. DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; TAS:ProtInc. DR GO; GO:0048487; F:beta-tubulin binding; IDA:UniProtKB. DR GO; GO:0050811; F:GABA receptor binding; IPI:UniProtKB. DR GO; GO:0006605; P:protein targeting; TAS:ProtInc. DR GO; GO:0007268; P:synaptic transmission; TAS:ProtInc. DR InterPro; IPR004241; MAP1_LC3. DR PANTHER; PTHR10969; MAP1_LC3; 1. DR Pfam; PF02991; MAP1_LC3; 1. PE 1: Evidence at protein level; KW 3D-structure; Cytoplasm; Cytoskeleton; Golgi apparatus; Membrane; KW Microtubule; Protein transport; Transport. FT CHAIN 1 117 Gamma-aminobutyric acid receptor- FT associated protein. FT /FTId=PRO_0000212363. FT REGION 1 22 Interaction with beta-tubulin. FT REGION 36 117 Interaction with GPHN (By similarity). FT REGION 36 68 Interaction with GABRG2 (Potential). FT HELIX 4 8 FT HELIX 11 24 FT STRAND 28 35 FT STRAND 48 52 FT HELIX 57 67 FT STRAND 77 80 FT HELIX 91 98 FT STRAND 105 111 SQ SEQUENCE 117 AA; 13918 MW; BC0B84B8A51C1E32 CRC64; MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGL //