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UniProtKB/Swiss-Prot entry O93937

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name PYR1_EMENI
Primary accession number O93937
Secondary accession numbers None
Integrated into Swiss-Prot on July 19, 2004
Sequence was last modified on May 1, 1999 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 52)
Name and origin of the protein
Protein name Protein pyrABCN
Synonyms None
Includes Glutamine-dependent carbamoyl-phosphate
     (EC 6.3.5.5)
Aspartate carbamoyltransferase
     (EC 2.1.3.2)
Gene name
Name: pyrABCN
From
Emericella nidulans (Aspergillus nidulans) [TaxID: 162425] 
Taxonomy Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Trichocomaceae; Emericella.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=FGSC 4;
PubMed=10417650 [NCBI, ExPASy, EBI, Israel, Japan]
Aleksenko A., Liu W., Gojkovic Z., Nielsen J., Piskur J.;
"Structural and transcriptional analysis of the pyrABCN, pyrD and pyrF genes in Aspergillus nidulans and the evolutionary origin of fungal dihydroorotases.";
Mol. Microbiol. 33:599-611(1999).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF112473; AAD09129.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P00968; 1M6V. [HSSP ENTRY / PDB]
ModBase O93937.
Ontologies
GO
GO:0016597; Molecular function: amino acid binding (inferred from electronic annotation from InterPro).
GO:0004070; Molecular function: aspartate carbamoyltransferase activity (traceable author statement from UniProtKB).
GO:0005524; Molecular function: ATP binding (inferred from electronic annotation from InterPro).
GO:0004088; Molecular function: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity (traceable author statement from UniProtKB).
GO:0006207; Biological process: 'de novo' pyrimidine base biosynthetic process (traceable author statement from UniProtKB).
GO:0006541; Biological process: glutamine metabolic process (inferred from electronic annotation from InterPro).
GO:0006221; Biological process: pyrimidine nucleotide biosynthetic process (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR006220; Anth_synthII.
IPR006130; Asp/Orn_carbamoyltranf.
IPR006132; Asp/Orn_carbamoyltranf_P_bd.
IPR006131; Asp_carbamoyltransf_Asp/Orn_bd.
IPR002082; Aspartate_carbamoyltransf_euk.
IPR011761; ATP-grasp.
IPR013816; ATP_grasp_subdomain_2.
IPR001317; CarbamoylP_synth_GATase.
IPR005483; CarbamoylP_synth_lsu.
IPR005479; CarbamoylP_synth_lsu_ATP-bd.
IPR006275; CarbamoylP_synth_lsu_Gln-dep.
IPR005481; CarbamoylP_synth_lsu_N.
IPR005480; CarbamoylP_synth_lsu_oligo.
IPR006274; CarbamoylP_synth_ssu.
IPR002474; CarbamoylP_synth_ssu_N.
IPR011702; GATASE.
IPR012998; GATase_1_AS.
IPR000991; GATase_class1_C.
IPR011607; MGS.
IPR013817; Pre-ATP_grasp.
Graphical view of domain structure.
Gene3D G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 2.
G3DSA:3.40.50.20; Pre-ATP_grasp; 2.
Pfam PF00289; CPSase_L_chain; 2.
PF02786; CPSase_L_D2; 2.
PF02787; CPSase_L_D3; 1.
PF00988; CPSase_sm_chain; 1.
PF00117; GATase; 1.
PF02142; MGS; 1.
PF00185; OTCace; 1.
PF02729; OTCace_N; 1.
Pfam graphical view of domain structure.
PRINTS PR00097; ANTSNTHASEII.
PR00100; AOTCASE.
PR00101; ATCASE.
PR00098; CPSASE.
PR00099; CPSGATASE.
PR00096; GATASE.
TIGRFAMs TIGR00670; asp_carb_tr; 1.
TIGR01369; CPSaseII_lrg; 1.
TIGR01368; CPSaseIIsmall; 1.
PROSITE PS50975; ATP_GRASP; 2.
PS00097; CARBAMOYLTRANSFERASE; 1.
PS00866; CPSASE_1; 2.
PS00867; CPSASE_2; 2.
PS51273; GATASE_TYPE_1; 1.
PROSITE graphical view of domain structure (profiles).
ProtoNet O93937.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Ligase; Multifunctional enzyme; Pyrimidine biosynthesis; Repeat; Transferase.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom    To Length Description FTId
CHAIN   1   2275  2275     Protein pyrABCN. PRO_0000199509
DOMAIN   265    453  189     Glutamine amidotransferase type-1. 
DOMAIN   604    796  193     ATP-grasp 1. 
DOMAIN   1139   1330  192     ATP-grasp 2. 
REGION   1    440  440     GATase (Glutamine amidotransferase) (By similarity). 
REGION   441    482  42     Linker (By similarity). 
REGION   483   1522  1040     CPSase (Carbamoyl-phosphate synthase) (By similarity). 
REGION   1523   1532  10     Linker (By similarity). 
REGION   1533   1862  330     Defective DHOase domain (By similarity). 
REGION   1863   1953  91     Linker (By similarity). 
REGION   1954   2258  305     ATCase (Aspartate transcarbamylase) (By similarity). 
ACT_SITE   342    342        For GATase activity (By similarity). 
ACT_SITE   426    426        For GATase activity (By similarity). 
ACT_SITE   428    428        For GATase activity (By similarity). 
Sequence information
Length: 2275 AA [This is the length of the unprocessed precursor] Molecular weight: 249741 Da [This is the MW of the unprocessed precursor] CRC64: 27BA9C1FA751436A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MPETVGHEEP ALPSSPQARG AVAYNAISKE LQPLPPTETA NGGIIPPASS RIEGSTGRLC 

        70         80         90        100        110        120 
ALELEDGTVY QGYNFGAEKS VAGELVFQTG MVGYPESITD PSYRGQILVI TFPLVGNYGV 

       130        140        150        160        170        180 
PSRETMDELL KTLPKHFEST EIHIAALVVA TYAGENYSHF LAESSLGQCV KEQGVPAIHG 

       190        200        210        220        230        240 
VDTRALTKRI RQKGSMLGRL LLHKADVAET DAALAQDTWK SSFEQIDWVD PNTKNLVSEV 

       250        260        270        280        290        300 
SIREPKLFSP PENVALKHPS SRPIRVLCLD VGLKFNQLRC LVARGVEVLV VPWDYDFPTL 

       310        320        330        340        350        360 
AGKDYDGLFV SNGPGDPATM TTTVNNLAKT MQEARTPIFG ICLGHQLIAR SVGAQTLKMK 

       370        380        390        400        410        420 
FGNRGHNIPC TSLVTGKCHI TSQNHGYAVD SSTLPSDWQE LFDNANDGSN EGIRHVSRPY 

       430        440        450        460        470        480 
FSVQFHPEST PGPRDTEYLF DVFINAIKDT IASAEALQKP VNFPGGAVAE NIKASPRVSV 

       490        500        510        520        530        540 
KKVLILGSGG LSIGQAGEFD YSGSQAIKAL KEEGIYTILI NPNIATIQTS KGLADKVYFL 

       550        560        570        580        590        600 
PVNADFVRKV IKHERPDAIY VTFGGQTALQ VGIQLKDEFE SLGVKVLGTP IDTIITTEDR 

       610        620        630        640        650        660 
ELFARSMDSI GEKCAKSASA SSLEEALQVV ESIGFPVIVR AAYALGGLGS GFADNLDELK 

       670        680        690        700        710        720 
DLCAKAFAAS PQVLIERSMK GWKEIEYEVV RDARDNCITV CNMENFDPLG IHTGDSIVVA 

       730        740        750        760        770        780 
PSQTLSDEDY NMLRTTAVNV IRHLGVVGEC NIQYALNPYS KEYCIIEVNA RLSRSSALAS 

       790        800        810        820        830        840 
KATGYPLAFI AAKLGLNIPL NEIKNSVTKV TCACFEPSLD YCVVKIPRWD LKKFTRVSTQ 

       850        860        870        880        890        900 
LGSSMKSVGE VMAIGRTFEE AIQKAIRSVD FHNLGFNETN ALMSIKTELQ TPSDQRLFAI 

       910        920        930        940        950        960 
ANAMAAGYRL DDIWKLTNID KWFLTRLKGL SDFGKLMTNY NASTVTAPLL RQAKQLGFSD 

       970        980        990       1000       1010       1020 
RQLAKFLSSN ELAIRRLRVE AGIIPIVKQI DTVAAEFPSV TNYLYLAYNA SEHDVRFDDN 

      1030       1040       1050       1060       1070       1080 
GIMVLGSGVY RIGSSVEFDW CSVRTIRTLR EQGHKTVMVN YNPETVSTDY DEADRLYFEN 

      1090       1100       1110       1120       1130       1140 
INLETVLDIY QLESSSGVIM SMGGQTPNNI ALPLHRLNVR ILGTSPEMID GAENRYKFSR 

      1150       1160       1170       1180       1190       1200 
MLDRIGVDQP AWKELTSIEE AREFCDKVGY PVLVRPSYVL SGAAMNTVYS EHDLASYLNQ 

      1210       1220       1230       1240       1250       1260 
AADVSREHPV VITKYIENAK EIEMDAVARN GVMVGHFISE HVENAGVHSG DATLILPPQD 

      1270       1280       1290       1300       1310       1320 
LDPETVRRIE EATRKIGNAL NVTGPFNIQF IAKDNDIKVI ECNVRASRSF PFVSKVMGVD 

      1330       1340       1350       1360       1370       1380 
LIEMATKAMI GAPFAEYPPV TIPKDYVGVK VPQFSFSRLA GADPVLGVEM ASTGEVASFG 

      1390       1400       1410       1420       1430       1440 
RDKYEAYLKA LLSTGFKLPK RNILLSIGSY KEKMEMLPSI IKLRDVGFEL FATSGTADFL 

      1450       1460       1470       1480       1490       1500 
KENGVPVKYL EILPGEDEDI KSEYSLTQHL ANNLIDLYIN LPSSNRFRRP ANYMSKGYRT 

      1510       1520       1530       1540       1550       1560 
RRMAVDYQTP LVTNVKNAKI LIEAIARHYA LNVQTIDYQT SHRSIILPGL INVGAFVPGL 

      1570       1580       1590       1600       1610       1620 
GSADSKDFEA VTKASIAAGF SMIRVMPVGV DSSITDARTL KLVQQNAGKA SFCDYNFSVV 

      1630       1640       1650       1660       1670       1680 
ATSSNSAEVG QLTGEVGSLF IPFNHLSGNI SKVAAVTSHF GAWPSSKPII TDAKSTDLAS 

      1690       1700       1710       1720       1730       1740 
VLLLASLHSR NIHVMSVTSK EDIGLIALSK EKGLKVTCDV SIYCLFLSRD DYPEAAFLPT 

      1750       1760       1770       1780       1790       1800 
REDQKALWEH LSTIDIFSIG SIPYQLAGEK GSPAAGIAEA LPLLFTAVSE GRLTVEDIIA 

      1810       1820       1830       1840       1850       1860 
RLYENPKKIF ELHDQSDSSV EVEIDRPYLF QSAQAWSPFS GKSVKGLVQR VIFQGKTSCL 

      1870       1880       1890       1900       1910       1920 
DSEITPDAPK GSDMSGHRIV PASPSLKAMS PRVDGALDRR QSISIAGTPA RLGRKPVDHF 

      1930       1940       1950       1960       1970       1980 
PAATGAELGP PLYTPVPRAS SPLLQMLSRS PFKQKHVLSV NQFNRADLHL LFTVAQEMRL 

      1990       2000       2010       2020       2030       2040 
GVQREGVLDI LKGRLLCTLF YEPSTRTSAS FDVAMQRLGG RTIAISTEHS STKKGETLQD 

      2050       2060       2070       2080       2090       2100 
TLRTLGCYGD AVVLRHPEPS STEVAAKFSP VPVINGGNGS VEHPTQAFLD LFTIREELGT 

      2110       2120       2130       2140       2150       2160 
VGGLTITFTG DLKYGRPVHS LIKLLQFYDV RVQLVAPKDL SLPADIRQQL LATGQLLTES 

      2170       2180       2190       2200       2210       2220 
EELTPEIVAR SDVLYSTRVQ KERFADLEQY ERLKNSFIID NALLKHAKSH MVVMHPLPRN 

      2230       2240       2250       2260       2270 
AEVSEEVDFD QRAAYFRLVS LQSRGPSSEF DMLMWMQMRY GLYCRMALIE LIMAP
O93937 in FASTA format

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