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UniProtKB/Swiss-Prot entry O93544

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDHA_DISMA
Primary accession number O93544
Secondary accession numbers None
Integrated into Swiss-Prot on December 5, 2001
Sequence was last modified on January 23, 2007 (Sequence version 3)
Annotations were last modified on    November 25, 2008 (Entry version 57)
Name and origin of the protein
Protein name L-lactate dehydrogenase A chain
Synonyms LDH-A
EC 1.1.1.27
Gene name
Name: ldha
From
Dissostichus mawsoni (Antarctic cod) [TaxID: 36200] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Euteleostei; Neoteleostei; Acanthomorpha; Acanthopterygii; Percomorpha; Perciformes; Notothenioidei; Nototheniidae; Dissostichus.
Protein existence 2: Evidence at transcript level;
References
[1]
 NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Muscle;
DOI=10.1073/pnas.95.19.11476; PubMed=9736762 [NCBI, ExPASy, EBI, Israel, Japan]
Fields P.A., Somero G.N.;
"Hot spots in cold adaptation: localized increases in conformational flexibility in lactate dehydrogenase A4 orthologs of Antarctic notothenioid fishes.";
Proc. Natl. Acad. Sci. U.S.A. 95:11476-11481(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF079827; AAC63285.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P00339; 9LDT. [HSSP ENTRY / PDB]
SMR O93544; 2-331.
ModBase O93544.
Ontologies
GO
GO:0005737; Cellular component: cytoplasm (inferred from electronic annotation from InterPro).
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004459; Molecular function: L-lactate dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0019642; Biological process: anaerobic glycolysis (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001557; L-lactate/malate_DHase.
IPR011304; L-lactate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
TIGRFAMs TIGR01771; L-LDH-NAD; 1.
PROSITE PS00064; L_LDH; 1.
ProtoNet O93544.
Phylogenomic databases
HOVERGEN O93544; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cytoplasm; Glycolysis; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
INIT_MET   1     1        Removed (By similarity). 
CHAIN   2   331  330     L-lactate dehydrogenase A chain. PRO_0000168436
NP_BIND   29    57  29     NAD (By similarity). 
ACT_SITE   192   192        Proton acceptor (By similarity). 
BINDING   98    98        NAD (By similarity). 
BINDING   105   105        Substrate (By similarity). 
BINDING   137   137        NAD or substrate (By similarity). 
BINDING   168   168        Substrate (By similarity). 
BINDING   247   247        Substrate (By similarity). 
Sequence information
Length: 331 AA [This is the length of the unprocessed precursor] Molecular weight: 36142 Da [This is the MW of the unprocessed precursor] CRC64: 3AA68DF03766FE65 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSTKEKLISH VMKEEPVGSR NKVTVVGVGM VGMASAISIL LKDLCDELAM VDVMEDKLKG 

        70         80         90        100        110        120 
EVMDLQHGSL FLKTKIVGDK DYSVTANSKV VVVTAGARQQ EGESRLNLVQ RNVNIFKFII 

       130        140        150        160        170        180 
PNIVKYSPNC ILMVVSNPVD ILTYVAWKLS GFPRNRVIGS GTNLDSARFR HLIGEKLHLH 

       190        200        210        220        230        240 
PSSCHAWIVG EHGDSSVPVW SGVNVAGVSL QGLNPQMGTE GDGENWKAIH KEVVDGAYEV 

       250        260        270        280        290        300 
IKLKGYTSWA IGMSVADLVE SIIKNMHKVH PVSTLVQGMH GVKDEVFLSV PSVLGNSGLT 

       310        320        330 
DVIHMTLKAE EEKQLQKSAE TLWGVQKELV L
O93544 in FASTA format

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