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UniProtKB/Swiss-Prot entry O83491

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name G6PD_TREPA
Primary accession number O83491
Secondary accession numbers None
Integrated into Swiss-Prot on December 15, 1998
Sequence was last modified on November 1, 1998 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 55)
Name and origin of the protein
Protein name Glucose-6-phosphate 1-dehydrogenase
Synonyms G6PD
EC 1.1.1.49
Gene name
Name: zwf
OrderedLocusNames: TP_0478
From
Treponema pallidum [TaxID: 160] [HAMAP proteome]
Taxonomy Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Treponema.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Nichols;
DOI=10.1126/science.281.5375.375; PubMed=9665876 [NCBI, ExPASy, EBI, Israel, Japan]
Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C.;
"Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
Science 281:375-388(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000520; AAC65465.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D71319; D71319.
RefSeq NP_218919.1; -.
3D structure databases
HSSP P11413; 1QKI. [HSSP ENTRY / PDB]
ModBase O83491.
Protein-protein interaction databases
IntAct O83491; -.
Enzyme and pathway databases
BioCyc TPAL243276:TP_0478-MON; -.
Ontologies
GO
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0004345; Molecular function: glucose-6-phosphate dehydrogenase activity (inferred from electronic annotation from InterPro).
GO:0006006; Biological process: glucose metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR001282; Glc-6-P_DHase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
PANTHER PTHR23429; G6PDH; 1.
Pfam PF02781; G6PD_C; 1.
PF00479; G6PD_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000110; G6PD; 1.
PRINTS PR00079; G6PDHDRGNASE.
ProDom PD001129; G6PD; 1.
[Domain structure / List of seq. sharing at least 1 domain]
TIGRFAMs TIGR00871; zwf; 1.
PROSITE PS00069; G6P_DEHYDROGENASE; 1.
ProtoNet O83491.
Genome annotation databases
GeneID 2611128; -.
GenomeReviews AE000520_GR; TP_0478.
KEGG tpa:TP0478; -.
NMPDR fig|243276.1.peg.478; -.
TIGR TP_0478; -.
Phylogenomic databases
HOGENOM O83491; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Carbohydrate metabolism; Complete proteome; Glucose metabolism; NADP; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   515  515     Glucose-6-phosphate 1-dehydrogenase. PRO_0000068137
ACT_SITE   252   252        Proton acceptor (By similarity). 
BINDING   21    21        NADP (By similarity). 
BINDING   53    53        NADP (By similarity). 
BINDING   190   190        Substrate (By similarity). 
BINDING   194   194        Substrate (By similarity). 
Sequence information
Length: 515 AA [This is the length of the unprocessed precursor] Molecular weight: 58032 Da [This is the MW of the unprocessed precursor] CRC64: 22936A1609EBD798 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MGKISGSGTV APHILVIFGA SGDLAARKLI PSLWDLFEQE LLPRTFGILG AGRTALSTES 

        70         80         90        100        110        120 
FRARLAEAVT KHAVRTPHDP ARLTEFLQKI HYFSFDPTDS VAFADFATYV RTLDQSLHTE 

       130        140        150        160        170        180 
GNFIFYLATP PSLYETIPTQ LAMHHLNREQ GNFRRVVIEK PFGYNLETAQ HLNASLRAHF 

       190        200        210        220        230        240 
QENQTYRIDH YLGKETVQNI LVTRFANPLF EPTWNRTHID YVEITASESL GVENRGGYYD 

       250        260        270        280        290        300 
QSGALRDMIQ NHLLLLLGII AMEAPAVVSS SRLRDEIVKV FDCLRPMGER DVMQHTVRAQ 

       310        320        330        340        350        360 
YVAGKIRGVA VPGYLEESGV DPRSCTETFA ALKCYIDNWR WMDVPFYLRT GKRLPTGVTE 

       370        380        390        400        410        420 
VIVHYRTLPI ALFEHIERPC AREGNALVIR IQPDEGIQLK IDLKEPGAGF KTIPVSVDFQ 

       430        440        450        460        470        480 
YSALTYSHLP SAYERLLLDC MNGDNTLYHR DDAVESAWRF IDPILAAWKS NKSPLLTYPA 

       490        500        510 
GSWGPKAADD LIKGSAPRWH HPSSTLLSDD FACRL
O83491 in FASTA format

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