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UniProtKB/Swiss-Prot entry O83080

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name LDHD_TREPA
Primary accession number O83080
Secondary accession numbers None
Integrated into Swiss-Prot on November 28, 2003
Sequence was last modified on November 1, 1998 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 51)
Name and origin of the protein
Protein name D-lactate dehydrogenase
Synonyms D-LDH
EC 1.1.1.28
D-specific D-2-hydroxyacid dehydrogenase
Gene name
Name: ldhD
OrderedLocusNames: TP_0037
From
Treponema pallidum [TaxID: 160] [HAMAP proteome]
Taxonomy Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Treponema.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Nichols;
DOI=10.1126/science.281.5375.375; PubMed=9665876 [NCBI, ExPASy, EBI, Israel, Japan]
Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G., Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A., Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D., Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O., Venter J.C.;
"Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
Science 281:375-388(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000520; AAC65033.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR D71373; D71373.
RefSeq NP_218477.1; -.
3D structure databases
HSSP P30901; 2DLD. [HSSP ENTRY / PDB]
ModBase O83080.
Protein-protein interaction databases
IntAct O83080; -.
Enzyme and pathway databases
BioCyc TPAL243276:TP_0037-MON; -.
Ontologies
GO
GO:0008720; Molecular function: D-lactate dehydrogenase activity (inferred from electronic annotation from EC).
GO:0051287; Molecular function: NAD binding (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR006139; D-isomer_2_OHA_DHase.
IPR006140; D-isomer_2_OHA_DHase_NAD-bd.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00389; 2-Hacid_dh; 1.
PF02826; 2-Hacid_dh_C; 1.
Pfam graphical view of domain structure.
PROSITE PS00065; D_2_HYDROXYACID_DH_1; 1.
PS00670; D_2_HYDROXYACID_DH_2; 1.
PS00671; D_2_HYDROXYACID_DH_3; 1.
ProtoNet O83080.
Genome annotation databases
GeneID 2611300; -.
GenomeReviews AE000520_GR; TP_0037.
KEGG tpa:TP0037; -.
NMPDR fig|243276.1.peg.36; -.
TIGR TP_0037; -.
Phylogenomic databases
HOGENOM O83080; -.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   331  331     D-lactate dehydrogenase. PRO_0000075971
ACT_SITE   235   235        By similarity. 
ACT_SITE   264   264        By similarity. 
ACT_SITE   296   296        Proton donor (By similarity). 
Sequence information
Length: 331 AA [This is the length of the unprocessed precursor] Molecular weight: 36873 Da [This is the MW of the unprocessed precursor] CRC64: 773B01E6E2384E0A [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRCVVFNLRE EEAPYVEKWK QSHPGVVVDT YEEPLTAKNK ELLKGYEGLV VMQFLAMEDE 

        70         80         90        100        110        120 
VYDYMGACKL KVLSTRTAGF DMYNATLLKK HGIRLTNVPS YSPNAIGEYA LAAALQLTRH 

       130        140        150        160        170        180 
AREIETFVRK RDFRWQKPIL SKELRCSRVG ILGTGRIGQA AARLFKGVGA QVVGFDPYPN 

       190        200        210        220        230        240 
DAAKEWLTYV SMDELLSTSD VISLHMPATK DSHHLINAKT IAQMKDGVYL VNTARGAVID 

       250        260        270        280        290        300 
SQALLDSLDK GKIAGAALDA YEFEGPYIPK DNGNNPITDT VYARLVAHER IIYTPHIAFY 

       310        320        330 
TETAIENMVF NSLDACTTVL RGEPCAAEIK L
O83080 in FASTA format

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