ID   PDX11_ARATH             Reviewed;         309 AA.
AC   O80448;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   22-JUL-2008, entry version 58.
DE   RecName: Full=Pyridoxal biosynthesis protein PDX1.1;
DE   AltName: Full=HEVER-like protein;
DE            Short=AtPDX1.1;
DE            Short=AtPDX1;2;
GN   Name=PDX11; Synonyms=PDX1L1; OrderedLocusNames=At2g38230;
GN   ORFNames=F16M14.16;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   MEDLINE=20083487; PubMed=10617197; DOI=10.1038/45471;
RA   Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA   Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA   Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L.,
RA   Moffat K.S., Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L.,
RA   Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H.,
RA   Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D.,
RA   Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M.,
RA   Venter J.C.;
RT   "Sequence and analysis of chromosome 2 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 402:761-768(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   MEDLINE=22954850; PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA   Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA   Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA   Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA   Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA   Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA   Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA   Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA   Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA   Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA   Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA   Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [3]
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=16157873; DOI=10.1073/pnas.0506228102;
RA   Tambasco-Studart M., Titiz O., Raschle T., Forster G., Amrhein N.,
RA   Fitzpatrick T.B.;
RT   "Vitamin B6 biosynthesis in higher plants.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13687-13692(2005).
RN   [4]
RP   TISSUE SPECIFICITY, AND INTERACTION WITH PDX1.2, PDX1.3 AND PDX2.
RC   STRAIN=cv. C24;
RX   PubMed=16766694; DOI=10.1105/tpc.105.036269;
RA   Wagner S., Bernhardt A., Leuendorf J.E., Drewke C., Lytovchenko A.,
RA   Mujahed N., Gurgui C., Frommer W.B., Leistner E., Fernie A.R.,
RA   Hellmann H.;
RT   "Analysis of the Arabidopsis rsr4-1/pdx1-3 mutant reveals the critical
RT   function of the PDX1 protein family in metabolism, development, and
RT   vitamin B6 biosynthesis.";
RL   Plant Cell 18:1722-1735(2006).
CC   -!- FUNCTION: Involved in the production of pyridoxal (vitamin B6) and
CC       indirect resistance to singlet oxygen-generating photosensitizers.
CC   -!- PATHWAY: Cofactor biosynthesis; pyridoxal 5'-phosphate
CC       biosynthesis.
CC   -!- SUBUNIT: Homodimer or heterodimer with PDX1.2 or PDX1.3. Interacts
CC       with PDX2.
CC   -!- INTERACTION:
CC       Q9ZNR6:PDX12; NbExp=1; IntAct=EBI-1545972, EBI-1545987;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- TISSUE SPECIFICITY: Expressed in flowers, shoots, leaves and
CC       weakly in roots.
CC   -!- MISCELLANEOUS: In plants, synthesis of vitamin B6 does not involve
CC       deoxyxylulose 5-phosphate but utilizes intermediates from the
CC       pentose phosphate pathway and from glycolysis.
CC   -!- MISCELLANEOUS: Vitamin B6 is an essential quencher of singlet
CC       oxygen in plants, that can protect cellular membranes from lipid
CC       peroxidation.
CC   -!- SIMILARITY: Belongs to the pdxS/SNZ family.
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DR   EMBL; AC003028; AAC27172.1; -; Genomic_DNA.
DR   EMBL; AF370296; AAK44111.1; -; mRNA.
DR   EMBL; AF385694; AAK60287.1; -; mRNA.
DR   EMBL; AY063043; AAL34217.1; -; mRNA.
DR   PIR; T01255; T01255.
DR   RefSeq; NP_181358.1; -.
DR   UniGene; At.68423; -.
DR   IntAct; O80448; -.
DR   ProMEX; O80448; -.
DR   GeneID; 818402; -.
DR   GenomeReviews; CT485783_GR; AT2G38230.
DR   KEGG; ath:AT2G38230; -.
DR   NMPDR; fig|3702.1.peg.10935; -.
DR   TAIR; At2g38230; -.
DR   GermOnline; AT2G38230; Arabidopsis thaliana.
DR   GO; GO:0005829; C:cytosol; IDA:TAIR.
DR   GO; GO:0046982; F:protein heterodimerization activity; IPI:TAIR.
DR   GO; GO:0042819; P:vitamin B6 biosynthetic process; IGI:TAIR.
DR   InterPro; IPR001852; Snz1p/Sor1.
DR   Pfam; PF01680; SOR_SNZ; 1.
DR   PIRSF; PIRSF029271; Pdx1; 1.
DR   ProDom; PD004958; Snz1p/Sor1; 1.
DR   TIGRFAMs; TIGR00343; Snz1p/Sor1; 1.
DR   PROSITE; PS01235; PDXS_SNZ_1; 1.
DR   PROSITE; PS51129; PDXS_SNZ_2; 1.
PE   1: Evidence at protein level;
KW   Complete proteome; Cytoplasm; Pyridoxine biosynthesis.
FT   CHAIN         1    309       Pyridoxal biosynthesis protein PDX1.1.
FT                                /FTId=PRO_0000109366.
SQ   SEQUENCE   309 AA;  32862 MW;  10D9EEDAEDC0BC4C CRC64;
     MAGTGVVAVY GEGAMTETKQ KSPFSVKVGL AQMLRGGVIM DVVNAEQARI AEEAGACAVM
     ALERVPADIR AQGGVARMSD PEMIKEIKNA VTIPVMAKAR IGHFVEAQIL EAIGVDYVDE
     SEVLTLADED NHINKHNFKI PFVCGCRNLG EALRRIREGA AMIRTKGEAG TGNVVEAVRH
     VRSVNGAIRL LRSMDDDEVF TYAKKIAAPY DLVVQTKELG RLPVVQFAAG GVATPADAAL
     MMQLGCDGVF VGSGVFKSGD PVKRAKAIVQ AVTNYRDAAV LAEVSCGLGE AMVGLNLDDK
     VERFASRSE
//