ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry O76093


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name FGF18_HUMAN
Primary accession number O76093
Secondary accession number Q6UWF1
Integrated into Swiss-Prot on July 15, 1999
Sequence was last modified on November 1, 1998 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 69)
Name and origin of the protein
Protein name Fibroblast growth factor 18 [Precursor]
Synonyms FGF-18
zFGF5
Gene name
Name: FGF18
ORFNames: UNQ420/PRO856
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
PubMed=9742123 [NCBI, ExPASy, EBI, Israel, Japan]
Hu M.C.-T., Qiu W.R., Wang Y.-P., Hill D., Ring B.D., Scully S., Bolon B., Derose M., Luethy R., Simonet W.S., Arakawa T., Danilenko D.M.;
"FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation.";
Mol. Cell. Biol. 18:6063-6074(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lung;
DOI=10.1074/jbc.273.29.18161; PubMed=9660775 [NCBI, ExPASy, EBI, Israel, Japan]
Ohbayashi N., Hoshikawa M., Kimura S., Yamasaki M., Fukui S., Ito N.;
"Structure and expression of the mRNA encoding a novel fibroblast growth factor, FGF-18.";
J. Biol. Chem. 273:18161-18164(1998).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
Deisher T., Conklin D., Raymond F., Bukowski T., Holderman S., Hansen B., Sheppard P., O'Hara P.;
"Homo sapiens homologue of fibroblast growth factor.";
Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.;
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Ovary;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-156.
DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan]
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.";
Genome Res. 13:2265-2270(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF075292; AAC62240.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AB007422; BAA31986.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF211188; AAF22977.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT019570; AAV38377.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BT019571; AAV38378.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC006245; AAH06245.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358811; AAQ89954.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_003853.1; -.
UniGene Hs.87191
3D structure databases
HSSP P31371; 1G82. [HSSP ENTRY / PDB]
ModBase O76093.
Enzyme and pathway databases
Reactome REACT_9470; Signaling by FGFR.
Organism-specific databases
H-InvDB HIX0005412; -.
HGNC HGNC:3674; FGF18.
GenAtlas FGF18.
MIM 603726; gene. [NCBI / EBI]
PharmGKB PA28113; -.
GeneCards O76093.
Gene expression databases
ArrayExpress O76093; -.
CleanEx HS_FGF18; -.
GermOnline ENSG00000156427; Homo sapiens.
Ontologies
GO
GO:0005615; Cellular component: extracellular space (traceable author statement from ProtInc).
GO:0005730; Cellular component: nucleolus (inferred from direct assay from LIFEdb).
GO:0008083; Molecular function: growth factor activity (traceable author statement from ProtInc).
GO:0009653; Biological process: anatomical structure morphogenesis (traceable author statement from ProtInc).
GO:0007267; Biological process: cell-cell signaling (traceable author statement from ProtInc).
GO:0008543; Biological process: fibroblast growth factor receptor signaling pathway (inferred from experiment from Reactome).
GO:0008284; Biological process: positive regulation of cell proliferation (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR002348; IL1_HBGF.
Graphical view of domain structure.
PANTHER PTHR11486; IL1_HBGF; 1.
Pfam PF00167; FGF; 1.
Pfam graphical view of domain structure.
PRINTS PR00262; IL1HBGF.
ProDom PD000831; IL1_HBGF; 1.
[Domain structure / List of seq. sharing at least 1 domain]
SMART SM00442; FGF; 1.
SMART graphical view of domain structure.
PROSITE PS00247; HBGF_FGF; 1.
BLOCKS O76093.
Genome annotation databases
Ensembl ENSG00000156427; Homo sapiens. [Contig view]
GeneID 8817; -.
KEGG hsa:8817; -.
Phylogenomic databases
HOGENOM O76093; -.
HOVERGEN O76093; -.
Other
SOURCE FGF18; Homo sapiens.
ProtoNet O76093.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Glycoprotein; Growth factor; Secreted; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    27  27     Potential. 
CHAIN   28   207  180     Fibroblast growth factor 18. PRO_0000008990
CARBOHYD   39    39        N-linked (GlcNAc...) (Potential). 
CARBOHYD   137   137        N-linked (GlcNAc...) (Potential). 
Sequence information
Length: 207 AA [This is the length of the unprocessed precursor] Molecular weight: 23989 Da [This is the MW of the unprocessed precursor] CRC64: 57F69E7B30181500 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MYSAPSACTC LCLHFLLLCF QVQVLVAEEN VDFRIHVENQ TRARDDVSRK QLRLYQLYSR 

        70         80         90        100        110        120 
TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK GKETEFYLCM NRKGKLVGKP 

       130        140        150        160        170        180 
DGTSKECVFI EKVLENNYTA LMSAKYSGWY VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK 

       190        200 
GQPELQKPFK YTTVTKRSRR IRPTHPA 

O76093 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA)
Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
 Hosted by ca flag CBR Canada Mirror sites: Australia  Brazil  China  Korea  Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!