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[1]
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NUCLEOTIDE SEQUENCE [MRNA], AND CHARACTERIZATION.
TISSUE=Brain;
DOI=10.1074/jbc.273.1.375; PubMed=9417091 [NCBI, ExPASy, EBI, Israel, Japan]
Wong S.H.,
Xu Y.,
Zhang T.,
Hong W.;
"Syntaxin 7, a novel syntaxin member associated with the early endosomal compartment.";
J. Biol. Chem. 273:375-380(1998).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA], AND SNARE COMPLEX CHARACTERIZATION.
DOI=10.1093/emboj/19.23.6453; PubMed=11101518 [NCBI, ExPASy, EBI, Israel, Japan]
Antonin W.,
Holroyd C.,
Fasshauer D.,
Pabst S.,
Fischer von Mollard G.,
Jahn R.;
"A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function.";
EMBO J. 19:6453-6464(2000).
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[3]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Heart;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[4]
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SNARE COMPLEX CHARACTERIZATION.
DOI=10.1038/sj.embor.7400150; PubMed=15133481 [NCBI, ExPASy, EBI, Israel, Japan]
Pryor P.R.,
Mullock B.M.,
Bright N.A.,
Lindsay M.R.,
Gray S.R.,
Richardson S.C.W.,
Stewart A.,
James D.E.,
Piper R.C.,
Luzio J.P.;
"Combinatorial SNARE complexes with VAMP7 or VAMP8 define different late endocytic fusion events.";
EMBO Rep. 5:590-595(2004).
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- FUNCTION: May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes (By similarity).
- SUBUNIT: Interacts with STX8. Forms a SNARE complex with VTI1B, STX8 and VAMP8 which functions in the homotypic fusion of late endosomes. Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes in liver cells. Interacts with VPS11, VPS16 and VPS18. Found in a complex with VAMP8 and VTI1B in the liver. Part of the SNARE core complex containing VAMP8, STX8 and VTI1B (By similarity). Interacts with VPS33A.
- SUBCELLULAR LOCATION: Early endosome membrane; Single-pass type IV membrane protein (By similarity).
- TISSUE SPECIFICITY: Detected in all tissues tested. Highest expression is found in kidney followed by lung, spleen, heart and brain. Lower expression, in skeletal muscle, liver and testis.
- SIMILARITY: Belongs to the syntaxin family.
- SIMILARITY: Contains 1 t-SNARE coiled-coil homology domain.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 261 AA [This is the length of the unprocessed precursor] |
Molecular weight: 29851 Da [This is the MW of the unprocessed precursor] |
CRC64: 42D23BA7EC5F5F09 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MSYTPGIGGD PAQLAQRISS NIQKITQCSA EIQRTLNQLG TPQDTPELRQ QLQQEQQYTN
70 80 90 100 110 120
QLAKETDKYI KEFGFLPTTP SEQRQRKIQK DRLVAEFTTA LTNFQKVQRQ AAEREKEFVA
130 140 150 160 170 180
RVRASSRVSG GFPEDSSKEK NFVSWESQTQ PQVQVQDEEI TEDDLRLIHE RESSIRQLEA
190 200 210 220 230 240
DIMDINEIFK DLGMMIHEQG DVIDSIEANV ESAEVHVQQA NQQLSRAANY QRKSRKTLCI
250 260
IILILVVGIV IIFFIVWGLK G
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O70257 in FASTA format |
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ExPASy Home page
CBR Canada
