[1]	NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). TISSUE=Fetal brain; DOI=10.1006/bbrc.1998.8239; PubMed=9514906 [NCBI, ExPASy, EBI, Israel, Japan] Hoshikawa M., Ohbayashi N., Yonamine A., Konishi M., Ozaki K., Fukui S., Itoh N.; "Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain."; Biochem. Biophys. Res. Commun. 244:187-191(1998).
[2]	NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Rieder M.J., Braun A.C., Montoya M.A., Chung M.-W., Nguyen C.P., Nguyen D.A., Livingston R.J., Poel C.L., Robertson P.D., Schackwitz W.S., Sherwood J.K., Witrak L.A., Nickerson D.A.; "NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu)."; Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
[3]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). DOI=10.1101/gr.1293003; PubMed=12975309 [NCBI, ExPASy, EBI, Israel, Japan] Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.; "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."; Genome Res. 13:2265-2270(2003).
[4]	NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan] The MGC Project Team; "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."; Genome Res. 14:2121-2127(2004).

Comments

FUNCTION: May be a signaling molecule in the induction and patterning of the embryonic brain.
SUBCELLULAR LOCATION: Secreted.

ALTERNATIVE PRODUCTS: 2 named isoforms [FASTA] produced by alternative splicing.

Name	1
Isoform ID	O60258-1
This is the isoform sequence displayed in this entry.

Name	2
Isoform ID	O60258-2
Note: No experimental confirmation available.
Features which should be applied to build the isoform sequence: VSP_008715.

TISSUE SPECIFICITY: Preferentially expressed in the embryonic brain.
DEVELOPMENTAL STAGE: Detected in embryos at E14.5, but not at E10.5 and E19.5. Preferentially expressed in the neuroepithelia of the isthmus and septum of the embryonic brain at E14.5.
SIMILARITY: Belongs to the heparin-binding growth factors family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

AB009249; BAA25429.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AF497475; AAM09570.1; -; Genomic_DNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
AY358869; AAQ89228.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC069475; AAH69475.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC105131; AAI05132.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]
BC113489; AAI13490.1; -; mRNA.	[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

NP_003858.1; -.

UniGene

Hs.248192

3D structure databases

HSSP

Q02195; 1QQK. [HSSP ENTRY / PDB]

SMR

O60258; 33-178.

ModBase

O60258.

Enzyme and pathway databases

Reactome

REACT_9470; Signaling by FGFR.

Polymorphism databases

NIEHS-SNPs

FGF17.

Organism-specific databases

HIX0007357; -.

HGNC:3673; FGF17.

603725; gene. [NCBI / EBI]

PharmGKB

PA28112; -.

GeneCards

O60258.

Gene expression databases

ArrayExpress

O60258; -.

CleanEx

HS_FGF17; -.

GermOnline

ENSG00000158815; Homo sapiens.

Ontologies

GO:0005615;	Cellular component: extracellular space (traceable author statement from ProtInc).
GO:0008083;	Molecular function: growth factor activity (traceable author statement from ProtInc).
GO:0007267;	Biological process: cell-cell signaling (traceable author statement from ProtInc).
GO:0008543;	Biological process: fibroblast growth factor receptor signaling pathway (inferred from experiment from Reactome).
GO:0007399;	Biological process: nervous system development (traceable author statement from ProtInc).
QuickGo view.

Family and domain databases

InterPro

IPR002348; IL1_HBGF.
Graphical view of domain structure.

PANTHER

PTHR11486; IL1_HBGF; 1.

Pfam

PF00167; FGF; 1.
Pfam graphical view of domain structure.

PRINTS

PR00262; IL1HBGF.

ProDom

PD000831; IL1_HBGF; 1.
[Domain structure / List of seq. sharing at least 1 domain]

SMART

SM00442; FGF; 1.
SMART graphical view of domain structure.

PROSITE

PS00247; HBGF_FGF; 1.

BLOCKS

O60258.

Genome annotation databases

Ensembl

ENSG00000158815; Homo sapiens. [Contig view]

GeneID

8822; -.

KEGG

hsa:8822; -.

Phylogenomic databases

HOGENOM

O60258; -.

HOVERGEN

O60258; -.

Other

FGF17; Homo sapiens.

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Alternative splicing; Glycoprotein; Growth factor; Secreted; Signal.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`SIGNAL`	`1 22`	`22`	`Potential.`
`CHAIN`	`23 216`	`194`	`Fibroblast growth factor 17.`	`PRO_0000008985`
`CARBOHYD`	`137 137`		`N-linked (GlcNAc...) (Potential).`
`VAR_SEQ`	`25 35`		`Missing (in isoform 2).`	`VSP_008715`

Sequence information

Length: 216 AA [This is the length of the unprocessed precursor]

Molecular weight: 24891 Da [This is the MW of the unprocessed precursor]

CRC64: 2EE0288675220F4C [This is a checksum on the sequence]

        10         20         30         40         50         60 
MGAARLLPNL TLCLQLLILC CQTQGENHPS PNFNQYVRDQ GAMTDQLSRR QIREYQLYSR 

        70         80         90        100        110        120 
TSGKHVQVTG RRISATAEDG NKFAKLIVET DTFGSRVRIK GAESEKYICM NKRGKLIGKP 

       130        140        150        160        170        180 
SGKSKDCVFT EIVLENNYTA FQNARHEGWF MAFTRQGRPR QASRSRQNQR EAHFIKRLYQ 

       190        200        210 
GQLPFPNHAE KQKQFEFVGS APTRRTKRTR RPQPLT

O60258 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools