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[1]
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NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=BALB/c;
TISSUE=Embryonic brain;
DOI=10.1007/s003359900531; PubMed=9271666 [NCBI, ExPASy, EBI, Israel, Japan]
Guilbaud C.,
Peyrard M.,
Fransson I.,
Clifton S.W.,
Roe B.A.,
Carter N.P.,
Dumanski J.P.;
"Characterization of the mouse beta-prime adaptin gene; cDNA sequence, genomic structure, and chromosomal localization.";
Mamm. Genome 8:651-656(1997).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Mammary gland;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[3]
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NITRATION [LARGE SCALE ANALYSIS] AT TYR-574, AND MASS SPECTROMETRY.
TISSUE=Brain;
DOI=10.1021/bi060474w; PubMed=16800626 [NCBI, ExPASy, EBI, Israel, Japan]
Sacksteder C.A.,
Qian W.-J.,
Knyushko T.V.,
Wang H.,
Chin M.H.,
Lacan G.,
Melega W.P.,
Camp D.G. II,
Smith R.D.,
Smith D.J.,
Squier T.C.,
Bigelow D.J.;
"Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease.";
Biochemistry 45:8009-8022(2006).
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- FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.
- SUBUNIT: Adaptor protein complex 1 (AP-1) is an heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).
- SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Golgi apparatus (By similarity). Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex (By similarity).
- TISSUE SPECIFICITY: Widely expressed.
- SIMILARITY: Belongs to the adaptor complexes large subunit family.
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 943 AA [This is the length of the unprocessed precursor] |
Molecular weight: 103979 Da [This is the MW of the unprocessed precursor] |
CRC64: 7A67869C1CAAF973 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MTDSKYFTTT KKGEIFELKA ELNSDKKEKK KEAVKKVIAS MTVGKDVSAL FPDVVNCMQT
70 80 90 100 110 120
DNLELKKLVY LYLMNYAKSQ PDMAIMAVNT FVKDCEDPNP LIRALAVRTM GCIRVDKITE
130 140 150 160 170 180
YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQLVEDQG FLDTLKDLIS DSNPMVVANA
190 200 210 220 230 240
VAALSEIAES HPSSNLLDLN PQSINKLLTA LNECTEWGQI FILDCLDNYM PKDDREAQSI
250 260 270 280 290 300
CERVTPRLSH ANSAVVLSAV KVLMKFMEML SKDLDYYATL LKKLAPPLVT LLSAEPELQY
310 320 330 340 350 360
VALRNINLIV QKRPEILKHE MKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE
370 380 390 400 410 420
YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIKDIFRK
430 440 450 460 470 480
YPNKYESVIA TLCENLDSLD EPEARAAMIW IVGEYAERID NADELLESFL EGFHDESTQV
490 500 510 520 530 540
QLQLLTAIVK LFLKKPTETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVAAKEV
550 560 570 580 590 600
VLAEKPLISE ETDLIEPTLL DELICYIGTL ASVYHKPPNA FVEGGRGVVH KSLPPRTASS
610 620 630 640 650 660
ESTESPETAP AGAPAGDQPD VIPAQGDLLG DLLNLDLGPP VSGPPLAASS VQMGAVDLLG
670 680 690 700 710 720
GGLDSLIGDS NFGAPSASVA AAPAPARLGA PISSGLSDLF DLTSGVGTLS GSYVAPKAVW
730 740 750 760 770 780
LPAMKAKGLE ISGTFTRQAG SISMDLQLTN KALQVMTDFA IQFNRNSFGL APAAPLQVHV
790 800 810 820 830 840
PLSPNQTVEI SLPLNTVGSV LKMEPLNNLQ VAVKNNIDVF YFSTLYPLHV LFVEDGKMDR
850 860 870 880 890 900
QMFLATWKDI ANENEAQFQI RDCPLNTEAA SNKLQSSNIF TVAKRNVEGQ DMLYQSLKLT
910 920 930 940
NGIWVLAELR IQPGNPSFTL SLKCRAPEVS QHVYQAYETI LKN
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O35643 in FASTA format |
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