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UniProtKB/Swiss-Prot entry O35118


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GFRA3_MOUSE
Primary accession number O35118
Secondary accession numbers O35325 O55243 Q6NZC2 Q8C8L9
Integrated into Swiss-Prot on July 19, 2004
Sequence was last modified on January 1, 1998 (Sequence version 1)
Annotations were last modified on    June 16, 2009 (Entry version 68)
Name and origin of the protein
Protein name GDNF family receptor alpha-3 [Precursor]
Synonym GFR-alpha-3
Gene name
Name: Gfra3
From
Mus musculus (Mouse) [TaxID: 10090] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6;
TISSUE=Heart;
DOI=10.1006/bbrc.1998.8361; PubMed=9535755 [NCBI, ExPASy, EBI, Israel, Japan]
Nomoto S., Ito S., Yang L.-X., Kiuchi K.;
"Molecular cloning and expression analysis of GFR alpha-3, a novel cDNA related to GDNFR alpha and NTNR-alpha.";
Biochem. Biophys. Res. Commun. 244:849-853(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1046/j.1460-9568.1998.00192.x; PubMed=9749804 [NCBI, ExPASy, EBI, Israel, Japan]
Widenfalk J., Tomac A., Lindqvist E., Hoffer B., Olson L.;
"GFRalpha-3, a protein related to GFRalpha-1, is expressed in developing peripheral neurons and ensheathing cells.";
Eur. J. Neurosci. 10:1508-1517(1998).
[3]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1073/pnas.95.3.1295; PubMed=9448325 [NCBI, ExPASy, EBI, Israel, Japan]
Naveilhan P., Baudet C., Mikaels A., Shen L., Westphal H., Ernfors P.;
"Expression and regulation of GFRalpha3, a glial cell line-derived neurotrophic factor family receptor.";
Proc. Natl. Acad. Sci. U.S.A. 95:1295-1300(1998).
[4]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1073/pnas.95.10.5801; PubMed=9576965 [NCBI, ExPASy, EBI, Israel, Japan]
Baloh R.H., Gorodinsky A., Golden J.P., Tansey M.G., Keck C.L., Popescu N.C., Johnson E.M. Jr., Milbrandt J.;
"GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family.";
Proc. Natl. Acad. Sci. U.S.A. 95:5801-5806(1998).
[5]
NUCLEOTIDE SEQUENCE [MRNA].
DOI=10.1006/mcne.1998.0667; PubMed=9608533 [NCBI, ExPASy, EBI, Israel, Japan]
Trupp M., Raynoschek C., Belluardo N., Ibanez C.F.;
"Multiple GPI-anchored receptors control GDNF-dependent and independent activation of the c-Ret receptor tyrosine kinase.";
Mol. Cell. Neurosci. 11:47-63(1998).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J;
TISSUE=Adrenal gland;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J., Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Pancreas;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AB008833; BAA23562.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF041842; AAC23558.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF036163; AAC24468.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF051766; AAC24354.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AF020305; AAB70931.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AK046542; BAC32778.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC066202; AAH66202.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00127451; -.
PIR JE0082; JE0082.
RefSeq NP_034410.3; -.
UniGene Mm.16520
3D structure databases
SMR O35118; 155-354.
ModBase O35118.
Organism-specific databases
MGI MGI:1201403; Gfra3.
Gene expression databases
ArrayExpress O35118; -.
Bgee O35118; -.
GermOnline ENSMUSG00000024366; Mus musculus.
Ontologies
GO
GO:0031225; Cellular component: anchored to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0009897; Cellular component: external side of plasma membrane (inferred from direct assay from MGI).
GO:0008046; Molecular function: axon guidance receptor activity (inferred from mutant phenotype from MGI).
GO:0015026; Molecular function: coreceptor activity (traceable author statement from MGI).
GO:0005515; Molecular function: protein binding (inferred from physical interaction from MGI).
GO:0007411; Biological process: axon guidance (inferred from mutant phenotype from MGI).
GO:0001764; Biological process: neuron migration (inferred from mutant phenotype from MGI).
GO:0048485; Biological process: sympathetic nervous system development (inferred from mutant phenotype from MGI).
GO:0007169; Biological process: transmembrane receptor protein tyrosine kinase signaling pathway (traceable author statement from MGI).
QuickGo view.
Family and domain databases
InterPro IPR016017; GDNF/GAS1.
IPR003438; GDNF_rcpt.
IPR003505; GDNF_rcpt_A3.
Graphical view of domain structure.
Pfam PF02351; GDNF; 3.
Pfam graphical view of domain structure.
PRINTS PR01319; GDNFRALPHA3.
PR01316; GDNFRECEPTOR.
Genome annotation databases
Ensembl ENSMUSG00000024366; Mus musculus. [Contig view]
GeneID 14587; -.
KEGG mmu:14587; -.
Phylogenomic databases
HOGENOM O35118; -.
HOVERGEN O35118; -.
OMA O35118; QDWADST.
Other
NextBio 286334; -.
SOURCE Gfra3; Mus musculus.
ProtoNet O35118.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Receptor; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    28  28     Potential. 
CHAIN   29   371  343     GDNF family receptor alpha-3. PRO_0000010791
PROPEP   372   397  26     Removed in mature form (Potential). PRO_0000010792
LIPID   371   371        GPI-anchor amidated asparagine (Potential). 
CARBOHYD   92    92        N-linked (GlcNAc...) (Potential). 
CARBOHYD   145   145        N-linked (GlcNAc...) (Potential). 
CARBOHYD   306   306        N-linked (GlcNAc...) (Potential). 
CONFLICT   5     6        WS -> LE (in Ref. 2 and 3). 
CONFLICT   66    66        S -> C (in Ref. 6; BAC32778). 
CONFLICT   218   218        A -> P (in Ref. 2, 3 and 5). 
CONFLICT   314   314        T -> S (in Ref. 7; AAH66202). 
Sequence information
Length: 397 AA [This is the length of the unprocessed precursor] Molecular weight: 44307 Da [This is the MW of the unprocessed precursor] CRC64: BB66CEF65D32A4B9 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MGLSWSPRPP LLMILLLVLS LWLPLGAGNS LATENRFVNS CTQARKKCEA NPACKAAYQH 

        70         80         90        100        110        120 
LGSCTSSLSR PLPLEESAMS ADCLEAAEQL RNSSLIDCRC HRRMKHQATC LDIYWTVHPA 

       130        140        150        160        170        180 
RSLGDYELDV SPYEDTVTSK PWKMNLSKLN MLKPDSDLCL KFAMLCTLHD KCDRLRKAYG 

       190        200        210        220        230        240 
EACSGIRCQR HLCLAQLRSF FEKAAESHAQ GLLLCPCAPE DAGCGERRRN TIAPSCALPS 

       250        260        270        280        290        300 
VTPNCLDLRS FCRADPLCRS RLMDFQTHCH PMDILGTCAT EQSRCLRAYL GLIGTAMTPN 

       310        320        330        340        350        360 
FISKVNTTVA LSCTCRGSGN LQDECEQLER SFSQNPCLVE AIAAKMRFHR QLFSQDWADS 

       370        380        390 
TFSVVQQQNS NPALRLQPRL PILSFSILPL ILLQTLW 

O35118 in FASTA format

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