[1]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lung;
DOI=10.1074/jbc.272.37.23191; PubMed=9287324 [NCBI, ExPASy, EBI, Israel, Japan]
Emoto H.,
Tagashira S.,
Mattei M.-G.,
Yamasaki M.,
Hashimoto G.,
Katsumata T.,
Negoro T.,
Nakatsuka M.,
Birnbaum D.,
Coulier F.,
Itoh N.;
"Structure and expression of human fibroblast growth factor-10.";
J. Biol. Chem. 272:23191-23194(1997).
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[2]
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NUCLEOTIDE SEQUENCE [MRNA].
TISSUE=Lung;
Jimenez P.A.,
Gruber J.R.,
Liu B.,
Feng P.,
Florence C.,
Blunt A.,
Huddleston K.A.,
Teliska M.,
Alfonso P.,
Coleman T.A.,
Ornitz D.M.,
Dillon P.A.,
Duan R.D.;
"Cutaneous wound healing by keratinocyte growth factor 2.";
Submitted (JUL-1997) to the EMBL/GenBank/DDBJ databases.
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[3]
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NUCLEOTIDE SEQUENCE [MRNA].
Zhang Y.,
Zhang B.,
Zhou Y.,
Peng X.,
Yuan J.,
Qiang B.;
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
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[4]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Halleck A.,
Ebert L.,
Mkoundinya M.,
Schick M.,
Eisenstein S.,
Neubert P.,
Kstrang K.,
Schatten R.,
Shen B.,
Henze S.,
Mar W.,
Korn B.,
Zuo D.,
Hu Y.,
LaBaer J.;
"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201).";
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
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[5]
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NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Livingston R.J.,
Rieder M.J.,
Chung M.-W.,
Ritchie T.K.,
Olson A.N.,
Nguyen C.P.,
Nguyen D.A.,
Poel C.L.,
Robertson P.D.,
Schackwitz W.S.,
Sherwood J.K.,
Sherwood A.M.,
Leithauser B.J.,
Nickerson D.A.;
"NIEHS-SNPs, environmental genome project, NIEHS ES15478, Department of Genome Sciences, Seattle, WA (URL: http://egp.gs.washington.edu).";
Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
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[6]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
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[7]
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INTERACTION WITH FGFBP1.
DOI=10.1038/sj.onc.1208560; PubMed=15806171 [NCBI, ExPASy, EBI, Israel, Japan]
Beer H.-D.,
Bittner M.,
Niklaus G.,
Munding C.,
Max N.,
Goppelt A.,
Werner S.;
"The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair.";
Oncogene 24:5269-5277(2005).
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[8]
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X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 69-208 IN COMPLEX WITH FGFR2.
DOI=10.1073/pnas.0436500100; PubMed=12591959 [NCBI, ExPASy, EBI, Israel, Japan]
Yeh B.K.,
Igarashi M.,
Eliseenkova A.V.,
Plotnikov A.N.,
Sher I.,
Ron D.,
Aaronson S.A.,
Mohammadi M.;
"Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors.";
Proc. Natl. Acad. Sci. U.S.A. 100:2266-2271(2003).
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[9]
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INVOLVEMENT IN ALSG.
DOI=10.1038/ng1507; PubMed=15654336 [NCBI, ExPASy, EBI, Israel, Japan]
Entesarian M.,
Matsson H.,
Klar J.,
Bergendal B.,
Olson L.,
Arakaki R.,
Hayashi Y.,
Ohuchi H.,
Falahat B.,
Bolstad A.I.,
Jonsson R.,
Wahren-Herlenius M.,
Dahl N.;
"Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands.";
Nat. Genet. 37:125-127(2005).
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[10]
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VARIANT LADDS ARG-156.
DOI=10.1111/j.1399-0004.2006.00597.x; PubMed=16630169 [NCBI, ExPASy, EBI, Israel, Japan]
Milunsky J.M.,
Zhao G.,
Maher T.A.,
Colby R.,
Everman D.B.;
"LADD syndrome is caused by FGF10 mutations.";
Clin. Genet. 69:349-354(2006).
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[11]
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VARIANT LADDS PHE-106.
DOI=10.1038/ng1757; PubMed=16501574 [NCBI, ExPASy, EBI, Israel, Japan]
Rohmann E.,
Brunner H.G.,
Kayserili H.,
Uyguner O.,
Nuernberg G.,
Lew E.D.,
Dobbie A.,
Eswarakumar V.P.,
Uzumcu A.,
Ulubil-Emeroglu M.,
Leroy J.G.,
Li Y.,
Becker C.,
Lehnerdt K.,
Cremers C.W.R.J.,
Yueksel-Apak M.,
Nuernberg P.,
Kubisch C.,
Schlessinger J., ![]()
van Bokhoven H.,
Wollnik B.;
"Mutations in different components of FGF signaling in LADD syndrome.";
Nat. Genet. 38:414-417(2006).
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- FUNCTION: Could be a growth factor active in the process of wound healing. Acts as a mitogen in the lung. May act in a manner similar to FGF-7.
- SUBUNIT: Interacts with FGFBP1.
- INTERACTION:
P21802:FGFR2; NbExp=1; IntAct=EBI-1035684, EBI-1028658;
- SUBCELLULAR LOCATION: Secreted (Potential).
- DISEASE: Defects in FGF10 are the cause of autosomal dominant aplasia of lacrimal and salivary glands (ALSG) [MIM:180920]. ALSG has variable expressivity, and affected individuals may have aplasia or hypoplasia of the lacrimal, parotid, submandibular and sublingual glands and absence of the lacrimal puncta. The disorder is characterized by irritable eyes, recurrent eye infections, epiphora (constant tearing) and xerostomia (dryness of the mouth), which increases the risk of dental erosion, dental caries, periodontal disease and oral infections.
- DISEASE: Defects in FGF10 are a cause of lacrimo-auriculo-dento-digital syndrome (LADDS) [MIM:149730]; also known as Levy-Hollister syndrome. LADDS is a form of ectodermal dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. LADDS is an autosomal dominant syndrome characterized by aplastic/hypoplastic lacrimal and salivary glands and ducts, cup-shaped ears, hearing loss, hypodontia and enamel hypoplasia, and distal limb segments anomalies. In addition to these cardinal features, facial dysmorphism, malformations of the kidney and respiratory system and abnormal genitalia have been reported. Craniosynostosis and severe syndactyly are not observed.
- SIMILARITY: Belongs to the heparin-binding growth factors family.
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