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UniProtKB/Swiss-Prot entry O00451


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GFRA2_HUMAN
Primary accession number O00451
Secondary accession numbers O15316 O15328 Q6GTR9 Q7Z5C2
Integrated into Swiss-Prot on November 1, 1997
Sequence was last modified on October 31, 2006 (Sequence version 2)
Annotations were last modified on    June 16, 2009 (Entry version 74)
Name and origin of the protein
Protein name GDNF family receptor alpha-2 [Precursor]
Synonyms GFR-alpha-2
Neurturin receptor alpha
NRTNR-alpha
NTNR-alpha
TGF-beta-related neurotrophic factor receptor 2
GDNF receptor beta
GDNFR-beta
RET ligand 2
Gene name
Name: GFRA2
Synonyms: GDNFRB, RETL2, TRNR2
From
Homo sapiens (Human) [TaxID: 9606] 
Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
Protein existence 2: Evidence at transcript level;
References
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
DOI=10.1016/S0896-6273(00)80318-9; PubMed=9182803 [NCBI, ExPASy, EBI, Israel, Japan]
Baloh R.H., Tansey M.G., Golden J.P., Creedon D.J., Heuckeroth R.O., Keck C.L., Zimonjic D.B., Popescu N.C., Johnson E.M. Jr., Milbrandt J.;
"TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.";
Neuron 18:793-802(1997).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Fetal brain;
DOI=10.1093/hmg/6.8.1267; PubMed=9259272 [NCBI, ExPASy, EBI, Israel, Japan]
Suvanto P., Wartiovaara K., Lindahl M., Arumae U., Moshnyakov M., Horelli-Kuitunen N., Airaksinen M.S., Palotie A., Sariola H., Saarma M.;
"Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha.";
Hum. Mol. Genet. 6:1267-1273(1997).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Liver;
DOI=10.1073/pnas.94.12.6238; PubMed=9177201 [NCBI, ExPASy, EBI, Israel, Japan]
Sanicola M., Hession C.A., Worley D.S., Carmillo P., Ehrenfels C., Walus L., Robinson S., Jaworski G., Wei H., Tizard R., Whitty A., Pepinsky R.B., Cate R.L.;
"Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins.";
Proc. Natl. Acad. Sci. U.S.A. 94:6238-6243(1997).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Yoong L.F., Too H.P.;
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
DOI=10.1101/gr.2596504; PubMed=15489334 [NCBI, ExPASy, EBI, Israel, Japan]
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AF002700; AAC52036.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U93703; AAB61922.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
U97145; AAC51647.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
AY326396; AAP88378.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
BC041688; AAH41688.1; -; mRNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
IPI IPI00011732; -.
IPI00398301; -.
RefSeq NP_001486.4; -.
UniGene Hs.441202
3D structure databases
ModBase O00451.
Organism-specific databases
GeneCards GC08M021593; -.
HGNC HGNC:4244; GFRA2.
GenAtlas GFRA2.
MIM 601956; gene. [NCBI / EBI]
PharmGKB PA28654; -.
Gene expression databases
ArrayExpress O00451; -.
Bgee O00451; -.
CleanEx HS_GFRA2; -.
GermOnline ENSG00000168546; Homo sapiens.
Ontologies
GO
GO:0031225; Cellular component: anchored to membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0019898; Cellular component: extrinsic to membrane (traceable author statement from ProtInc).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-SubCell).
GO:0016167; Molecular function: glial cell line-derived neurotrophic factor receptor activity (traceable author statement from ProtInc).
GO:0007169; Biological process: transmembrane receptor protein tyrosine kinase signaling pathway (traceable author statement from ProtInc).
QuickGo view.
Family and domain databases
InterPro IPR016017; GDNF/GAS1.
IPR003438; GDNF_rcpt.
IPR003504; GDNF_rcpt_a2.
IPR017372; Glial_neurotroph_fac_rcpt_a1/2.
Graphical view of domain structure.
Pfam PF02351; GDNF; 3.
Pfam graphical view of domain structure.
PIRSF PIRSF038071; GDNF_family_receptor_alpha; 1.
PRINTS PR01318; GDNFRALPHA2.
PR01316; GDNFRECEPTOR.
Proteomic databases
PRIDE O00451; -.
Genome annotation databases
Ensembl ENSG00000168546; Homo sapiens. [Contig view]
GeneID 2675; -.
KEGG hsa:2675; -.
Phylogenomic databases
HOGENOM O00451; -.
HOVERGEN O00451; -.
OMA O00451; SPYEPVT.
Other
NextBio 10560; -.
SOURCE GFRA2; Homo sapiens.
ProtoNet O00451.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Alternative splicing; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Receptor; Signal.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
SIGNAL   1    21  21     Potential. 
CHAIN   22   444  423     GDNF family receptor alpha-2. PRO_0000010785
PROPEP   445   464  20     Removed in mature form (Potential). PRO_0000010786
LIPID   444   444        GPI-anchor amidated serine (Potential). 
CARBOHYD   52    52        N-linked (GlcNAc...) (Potential). 
CARBOHYD   357   357        N-linked (GlcNAc...) (Potential). 
CARBOHYD   413   413        N-linked (GlcNAc...) (Potential). 
VAR_SEQ   14   146        Missing (in isoform 2). VSP_001661
CONFLICT   6     6        V -> A (in Ref. 2; AAB61922). 
CONFLICT   462   462        L -> Q (in Ref. 1; AAC52036, 2; AAB61922 and 4; AAP88378). 
Sequence information
Length: 464 AA [This is the length of the unprocessed precursor] Molecular weight: 51544 Da [This is the MW of the unprocessed precursor] CRC64: 8BC61529530FF21F [This is a checksum on the sequence]
        10         20         30         40         50         60 
MILANVFCLF FFLDETLRSL ASPSSLQGPE LHGWRPPVDC VRANELCAAE SNCSSRYRTL 

        70         80         90        100        110        120 
RQCLAGRDRN TMLANKECQA ALEVLQESPL YDCRCKRGMK KELQCLQIYW SIHLGLTEGE 

       130        140        150        160        170        180 
EFYEASPYEP VTSRLSDIFR LASIFSGTGA DPVVSAKSNH CLDAAKACNL NDNCKKLRSS 

       190        200        210        220        230        240 
YISICNREIS PTERCNRRKC HKALRQFFDR VPSEYTYRML FCSCQDQACA ERRRQTILPS 

       250        260        270        280        290        300 
CSYEDKEKPN CLDLRGVCRT DHLCRSRLAD FHANCRASYQ TVTSCPADNY QACLGSYAGM 

       310        320        330        340        350        360 
IGFDMTPNYV DSSPTGIVVS PWCSCRGSGN MEEECEKFLR DFTENPCLRN AIQAFGNGTD 

       370        380        390        400        410        420 
VNVSPKGPSF QATQAPRVEK TPSLPDDLSD STSLGTSVIT TCTSVQEQGL KANNSKELSM 

       430        440        450        460 
CFTELTTNII PGSNKVIKPN SGPSRARPSA ALTVLSVLML KLAL 

O00451 in FASTA format

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