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[1]
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NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 17 AND 20).
TISSUE=Brain;
DOI=10.1016/S0378-1119(99)00253-X; PubMed=10433968 [NCBI, ExPASy, EBI, Israel, Japan]
Sagane K.,
Yamazaki K.,
Mizui Y.,
Tanaka I.;
"Cloning and chromosomal mapping of mouse ADAM11, ADAM22 and ADAM23.";
Gene 236:79-86(1999).
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[2]
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NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-904 (ISOFORM 2).
STRAIN=C57BL/6J;
TISSUE=Embryo;
DOI=10.1126/science.1112014; PubMed=16141072 [NCBI, ExPASy, EBI, Israel, Japan]
Carninci P.,
Kasukawa T.,
Katayama S.,
Gough J.,
Frith M.C.,
Maeda N.,
Oyama R.,
Ravasi T.,
Lenhard B.,
Wells C.,
Kodzius R.,
Shimokawa K.,
Bajic V.B.,
Brenner S.E.,
Batalov S.,
Forrest A.R.,
Zavolan M.,
Davis M.J.,
Wilming L.G., ![]()
Aidinis V.,
Allen J.E.,
Ambesi-Impiombato A.,
Apweiler R.,
Aturaliya R.N.,
Bailey T.L.,
Bansal M.,
Baxter L.,
Beisel K.W.,
Bersano T.,
Bono H.,
Chalk A.M.,
Chiu K.P.,
Choudhary V.,
Christoffels A.,
Clutterbuck D.R.,
Crowe M.L.,
Dalla E.,
Dalrymple B.P.,
de Bono B.,
Della Gatta G.,
di Bernardo D.,
Down T.,
Engstrom P.,
Fagiolini M.,
Faulkner G.,
Fletcher C.F.,
Fukushima T.,
Furuno M.,
Futaki S.,
Gariboldi M.,
Georgii-Hemming P.,
Gingeras T.R.,
Gojobori T.,
Green R.E.,
Gustincich S.,
Harbers M.,
Hayashi Y.,
Hensch T.K.,
Hirokawa N.,
Hill D.,
Huminiecki L.,
Iacono M.,
Ikeo K.,
Iwama A.,
Ishikawa T.,
Jakt M.,
Kanapin A.,
Katoh M.,
Kawasawa Y.,
Kelso J.,
Kitamura H.,
Kitano H.,
Kollias G.,
Krishnan S.P.,
Kruger A.,
Kummerfeld S.K.,
Kurochkin I.V.,
Lareau L.F.,
Lazarevic D.,
Lipovich L.,
Liu J.,
Liuni S.,
McWilliam S.,
Madan Babu M.,
Madera M.,
Marchionni L.,
Matsuda H.,
Matsuzawa S.,
Miki H.,
Mignone F.,
Miyake S.,
Morris K.,
Mottagui-Tabar S.,
Mulder N.,
Nakano N.,
Nakauchi H.,
Ng P.,
Nilsson R.,
Nishiguchi S.,
Nishikawa S.,
Nori F.,
Ohara O.,
Okazaki Y.,
Orlando V.,
Pang K.C.,
Pavan W.J.,
Pavesi G.,
Pesole G.,
Petrovsky N.,
Piazza S.,
Reed J.,
Reid J.F.,
Ring B.Z.,
Ringwald M.,
Rost B.,
Ruan Y.,
Salzberg S.L.,
Sandelin A.,
Schneider C.,
Schoenbach C.,
Sekiguchi K.,
Semple C.A.,
Seno S.,
Sessa L.,
Sheng Y.,
Shibata Y.,
Shimada H.,
Shimada K.,
Silva D.,
Sinclair B.,
Sperling S.,
Stupka E.,
Sugiura K.,
Sultana R.,
Takenaka Y.,
Taki K.,
Tammoja K.,
Tan S.L.,
Tang S.,
Taylor M.S.,
Tegner J.,
Teichmann S.A.,
Ueda H.R.,
van Nimwegen E.,
Verardo R.,
Wei C.L.,
Yagi K.,
Yamanishi H.,
Zabarovsky E.,
Zhu S.,
Zimmer A.,
Hide W.,
Bult C.,
Grimmond S.M.,
Teasdale R.D.,
Liu E.T.,
Brusic V.,
Quackenbush J.,
Wahlestedt C.,
Mattick J.S.,
Hume D.A.,
Kai C.,
Sasaki D.,
Tomaru Y.,
Fukuda S.,
Kanamori-Katayama M.,
Suzuki M.,
Aoki J.,
Arakawa T.,
Iida J.,
Imamura K.,
Itoh M.,
Kato T.,
Kawaji H.,
Kawagashira N.,
Kawashima T.,
Kojima M.,
Kondo S.,
Konno H.,
Nakano K.,
Ninomiya N.,
Nishio T.,
Okada M.,
Plessy C.,
Shibata K.,
Shiraki T.,
Suzuki S.,
Tagami M.,
Waki K.,
Watahiki A.,
Okamura-Oho Y.,
Suzuki H.,
Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
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[3]
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NUCLEOTIDE SEQUENCE [MRNA] OF 709-904 (ISOFORMS 1; 2; 3; 4; 5; 6; 7; 8; 9; 10; 11; 12; 13; 14; 15; 16; 17; 18; 19; 20 AND 21), TISSUE SPECIFICITY, AND NULL MUTANT.
DOI=10.1186/1471-2202-6-33; PubMed=15876356 [NCBI, ExPASy, EBI, Israel, Japan]
Sagane K.,
Hayakawa K.,
Kai J.,
Hirohashi T.,
Takahashi E.,
Miyamoto N.,
Ino M.,
Oki T.,
Yamazaki K.,
Nagasu T.;
"Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice.";
BMC Neurosci. 6:33-33(2005).
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[4]
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PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-832; SER-864 AND SER-866, AND MASS SPECTROMETRY.
TISSUE=Brain cortex;
DOI=10.1074/mcp.M600046-MCP200; PubMed=17114649 [NCBI, ExPASy, EBI, Israel, Japan]
Munton R.P.,
Tweedie-Cullen R.,
Livingstone-Zatchej M.,
Weinandy F.,
Waidelich M.,
Longo D.,
Gehrig P.,
Potthast F.,
Rutishauser D.,
Gerrits B.,
Panse C.,
Schlapbach R.,
Mansuy I.M.;
"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.";
Mol. Cell. Proteomics 6:283-293(2007).
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- FUNCTION: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation (By similarity).
- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
- ALTERNATIVE PRODUCTS:
21 named isoforms [FASTA] produced by alternative splicing.
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| Name | 2 |
| Synonyms | ADAM22-G03, 22g(D27) |
| Isoform ID | Q9R1V6-4 |
| Features which should be applied to build the isoform sequence: VSP_018238. |
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| Name | 3 |
| Synonyms | ADAM22-G06, 22g(D26D27) |
| Isoform ID | Q9R1V6-5 |
| Features which should be applied to build the isoform sequence: VSP_018235. |
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| Name | 4 |
| Synonyms | ADAM22=G07, 22g(D26D27)+29.3 |
| Isoform ID | Q9R1V6-6 |
| Features which should be applied to build the isoform sequence: VSP_018235, VSP_018245. |
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| Name | 5 |
| Synonyms | ADAM22-G08, 22g(D27)+29.3 |
| Isoform ID | Q9R1V6-7 |
| Features which should be applied to build the isoform sequence: VSP_018238, VSP_018245. |
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| Name | 6 |
| Synonyms | ADAM22-G09, 22g+29.3 |
| Isoform ID | Q9R1V6-8 |
| Features which should be applied to build the isoform sequence: VSP_018245. |
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| Name | 7 |
| Synonyms | ADAM22-G10, 22g+29.1 |
| Isoform ID | Q9R1V6-9 |
| Features which should be applied to build the isoform sequence: VSP_018241. |
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| Name | 8 |
| Synonyms | ADAM22-G11, 22g(D27)+29.5+29.7 |
| Isoform ID | Q9R1V6-10 |
| Features which should be applied to build the isoform sequence: VSP_018238, VSP_018246. |
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| Name | 9 |
| Synonyms | ADAM22-G12, 22g+29.3+29.7 |
| Isoform ID | Q9R1V6-11 |
| Features which should be applied to build the isoform sequence: VSP_018247. |
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| Name | 10 |
| Synonyms | ADAM22-G17, 22G[27L]+29.3+29.7 |
| Isoform ID | Q9R1V6-12 |
| Features which should be applied to build the isoform sequence: VSP_018239, VSP_018242. |
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| Name | 11 |
| Synonyms | ADAM22-G18, 22g(D26)[27L] |
| Isoform ID | Q9R1V6-13 |
| Features which should be applied to build the isoform sequence: VSP_018236, VSP_018239. |
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| Name | 12 |
| Synonyms | ADAM22-G19, 22g[27L]+29.5 |
| Isoform ID | Q9R1V6-14 |
| Features which should be applied to build the isoform sequence: VSP_018239, VSP_018243. |
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| Name | 13 |
| Synonyms | ADAM22-G20, 22g[27L] |
| Isoform ID | Q9R1V6-15 |
| Features which should be applied to build the isoform sequence: VSP_018239. |
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| Name | 14 |
| Synonyms | ADAM22-G21, 22g(D26)[27S] |
| Isoform ID | Q9R1V6-16 |
| Features which should be applied to build the isoform sequence: VSP_018234. |
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| Name | 15 |
| Synonyms | ADAM22-G22, 22g(D27)+29.7 |
| Isoform ID | Q9R1V6-17 |
| Features which should be applied to build the isoform sequence: VSP_018238, VSP_018244. |
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| Name | 16 |
| Synonyms | ADAM22-G23, 22g(D25D26D27) |
| Isoform ID | Q9R1V6-18 |
| Features which should be applied to build the isoform sequence: VSP_018233. |
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| Name | 20 |
| Synonyms | ADAM22-A04, Alpha |
| Isoform ID | Q9R1V6-1 |
| Features which should be applied to build the isoform sequence: VSP_018248. |
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- TISSUE SPECIFICITY: Expressed at high levels in the brain. Strongly expressed in cerebellar granule cells and hippocampus. In spinal cord, expression is restricted to gray matter.
- PTM: The precursor is cleaved by a furin endopeptidase (By similarity).
- MISCELLANEOUS: Mice lacking Adam22 display severe ataxia within one week after birth and die before weaning, probably due to convulsions. They display marked hypomyelination of the peripheral nerves.
- SIMILARITY: Contains 1 disintegrin domain.
- SIMILARITY: Contains 1 EGF-like domain.
- SIMILARITY: Contains 1 peptidase M12B domain [view classification].
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Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms.
Distributed under the Creative Commons Attribution-NoDerivs License.
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| Length: 904 AA [This is the length of the unprocessed precursor] |
Molecular weight: 99715 Da [This is the MW of the unprocessed precursor] |
CRC64: 0FBBD09398EE0B97 [This is a checksum on the sequence] |
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10 20 30 40 50 60
MQAAAAASFW LLCVLGTCPL ARCGRAGVAS LKGLERGKEN RFLERQSIIP LRLIYRLGGE
70 80 90 100 110 120
DETQHNQLDT RVRGDPGGPQ LTHVDKASFR VDAFGTSFVL DVLLNHELLS SGYVERQIEH
130 140 150 160 170 180
GGKVVENKGG EHCYYQGQIR GNPVSFVALS TCHGLHGMFY DGNHTYLIEP EENEKSQESS
190 200 210 220 230 240
HCHSVYKSRQ FEFPLDDLPS EFQRVNITPP QFILKPRLKR RKRQLLRFPR NVEEETKYIE
250 260 270 280 290 300
LMIVNDHLMF KKHRLSVVYT NTYAKSVVNM ADVIYKDQLK TRIVLVAMET WAADNKFAIS
310 320 330 340 350 360
ENPLITLREF MKYRRDFIKE KADAVHLFSG SQFESSRSGA AYIGGICSLL RGGGVNEFGK
370 380 390 400 410 420
TDLMAVTLAQ SLAHNVGIIS DKRKLASGEC KCEDTWSGCI MGDTGYYLPK KFTQCNVEEY
430 440 450 460 470 480
HDFLNSGGGA CLFNKPSKLL DPPECGNGFI ETGEECDCGT PAECALEGAE CCKKCTLTQD
490 500 510 520 530 540
SQCSDGLCCK KCKFQPLGTV CREAVNDCDI REICSGNSSQ CAPNVHKMDG YSCDGTQGIC
550 560 570 580 590 600
FGGRCKTRDR QCKYIWGQKV TASDRYCYEK LNIEGTEKGN CGKDKDTWTQ CNKRDVLCGY
610 620 630 640 650 660
LLCTNIGNIP RLGELDGEIT STLVVQQGRT LNCSGAHVKL EEDVDLGYVE DGTPCGPQMM
670 680 690 700 710 720
CLEHRCLPVA SFNFSTCSSS KAGTVCSGNG VCSNELKCVC NRHWTGADCG THFPHNDDAK
730 740 750 760 770 780
TGITLSGNGV AGTNIIIGII AGTILVLALI LGITAWGYKN YREQRQLPQG DYVKKPGDGD
790 800 810 820 830 840
SFYSDFPPGG STNSASSSKK RSNGLSHSWS ERIPDTKHIS DICENGRPRS NSWQGNMGGN
850 860 870 880 890 900
KKKIRGKRFR PRSNSTETLS PAKSPSSSTG SIASSRKYPY PMPPLPDEGK TAGRQSARLW
ETSI
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Q9R1V6 in FASTA format |
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