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UniProtKB/Swiss-Prot entry A8GC31

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAO1_SERP5
Primary accession number A8GC31
Secondary accession numbers None
Integrated into Swiss-Prot on February 5, 2008
Sequence was last modified on November 13, 2007 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 9)
Name and origin of the protein
Protein name NAD-dependent malic enzyme
Synonyms NAD-ME
EC 1.1.1.38
Gene name
Name: sfcA
OrderedLocusNames: Spro_1567
From
Serratia proteamaculans (strain 568) [TaxID: 399741] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Serratia.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Chain P., Malfatti S., Shin M., Vergez L., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Kim E., Taghavi S., Newman L., Vangronsveld J., van der Lelie D., Richardson P.;
"Complete sequence of chromosome of Serratia proteamaculans 568.";
Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000826; ABV40671.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001477799.1; -.
3D structure databases
ModBase A8GC31.
Ontologies
GO
GO:0016619; Molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) activity (inferred from electronic annotation from HAMAP).
GO:0046872; Molecular function: metal ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01619; -; 1.
PBIL [Tree]
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR001891; Malic_OxRdtase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
Pfam graphical view of domain structure.
PRINTS PR00072; MALOXRDTASE.
PROSITE PS00331; MALIC_ENZYMES; 1.
BLOCKS A8GC31.
ProtoNet A8GC31.
Genome annotation databases
GeneID 5602866; -.
GenomeReviews CP000826_GR; Spro_1567.
KEGG spe:Spro_1567; -.
CMR A8GC31; Spro_1567.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   565  565     NAD-dependent malic enzyme. PRO_1000069537
ACT_SITE   104   104        Proton donor (By similarity). 
ACT_SITE   175   175        Proton acceptor (By similarity). 
METAL   246   246        Divalent metal cation (By similarity). 
METAL   247   247        Divalent metal cation (By similarity). 
METAL   270   270        Divalent metal cation (By similarity). 
BINDING   157   157        NAD (By similarity). 
BINDING   270   270        NAD (By similarity). 
BINDING   418   418        NAD (By similarity). 
SITE   270   270  1     Important for activity (By similarity). 
Sequence information
Length: 565 AA [This is the length of the unprocessed precursor] Molecular weight: 62750 Da [This is the MW of the unprocessed precursor] CRC64: ACD380A89DEABC20 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MELEYESKRP LYIPYAGPIL LEFPLLNKGS AFTEEERNHF NLQGLLPDAV ETIEEQAERA 

        70         80         90        100        110        120 
YRQYQDFKND SDKHIYLRNI QDTNETLFYR LLDSHLSEMM PIIYTPTVGE ACEHFSDIYR 

       130        140        150        160        170        180 
RARGLFISYP NRDRIDDMLQ NATKQNVKVI VVTDGERILG LGDQGIGGMG IPIGKLSLYT 

       190        200        210        220        230        240 
ACGGISPAYT LPVVLDVGTN NPQRLNDPLY MGWRHPRISG DEYHAFVEEF IQAVKRRWPN 

       250        260        270        280        290        300 
VLLQFEDFAQ NNATPLLNRY RDEICCFNDD IQGTAAVTLG SLIAASRAAG SQLRDQTVTF 

       310        320        330        340        350        360 
LGAGSAGCGI AEQIIAQMKS EGLSEDEARA RVFMVDRFGL LTDKLPNLLD FQSKLVQKSE 

       370        380        390        400        410        420 
NLTAWQTQSD AISLLDVVRN AKPTILIGVS GQPGLFTEEL IREMHKHCPR PIVMPLSNPT 

       430        440        450        460        470        480 
SRVEARPEDI INWTEGAALV ATGSPFAPVH YKEQQIPIAQ CNNSYIFPGI GLGVLASGAT 

       490        500        510        520        530        540 
RVTDAMLMAA SRALAECSPL ATDGHGALLP DIDDIQGVSK CIAMEVGKAA QLQGMAVVTS 

       550        560 
EEALSKAIEH NFWRPQYRSY KRTSF
A8GC31 in FASTA format

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