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UniProtKB/Swiss-Prot entry A8AGN6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MAO1_CITK8
Primary accession number A8AGN6
Secondary accession numbers None
Integrated into Swiss-Prot on February 5, 2008
Sequence was last modified on October 23, 2007 (Sequence version 1)
Annotations were last modified on    November 4, 2008 (Entry version 11)
Name and origin of the protein
Protein name NAD-dependent malic enzyme
Synonyms NAD-ME
EC 1.1.1.38
Gene name
Name: sfcA
OrderedLocusNames: CKO_01517
From
Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) [TaxID: 290338] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Citrobacter.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
McClelland M., Sanderson E.K., Porwollik S., Spieth J., Clifton W.S., Latreille P., Courtney L., Wang C., Pepin K., Bhonagiri V., Nash W., Johnson M., Thiruvilangam P., Wilson R.;
Submitted (AUG-2007) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000822; ABV12649.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001453085.1; -.
3D structure databases
ModBase A8AGN6.
Ontologies
GO
GO:0016619; Molecular function: malate dehydrogenase (oxaloacetate-decarboxylating) activity (inferred from electronic annotation from HAMAP).
GO:0046872; Molecular function: metal ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_01619; -; 1.
PBIL [Tree]
InterPro IPR015884; Malic_enzyme_CS.
IPR012301; Malic_N.
IPR012302; Malic_NAD_bd.
IPR001891; Malic_OxRdtase.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF00390; malic; 1.
PF03949; Malic_M; 1.
Pfam graphical view of domain structure.
PRINTS PR00072; MALOXRDTASE.
PROSITE PS00331; MALIC_ENZYMES; 1.
BLOCKS A8AGN6.
ProtoNet A8AGN6.
Genome annotation databases
GeneID 5583553; -.
GenomeReviews CP000822_GR; CKO_01517.
KEGG cko:CKO_01517; -.
CMR A8AGN6; CKO_01517.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Metal-binding; NAD; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   565  565     NAD-dependent malic enzyme. PRO_1000069527
ACT_SITE   104   104        Proton donor (By similarity). 
ACT_SITE   175   175        Proton acceptor (By similarity). 
METAL   246   246        Divalent metal cation (By similarity). 
METAL   247   247        Divalent metal cation (By similarity). 
METAL   270   270        Divalent metal cation (By similarity). 
BINDING   157   157        NAD (By similarity). 
BINDING   270   270        NAD (By similarity). 
BINDING   418   418        NAD (By similarity). 
SITE   270   270  1     Important for activity (By similarity). 
Sequence information
Length: 565 AA [This is the length of the unprocessed precursor] Molecular weight: 63172 Da [This is the MW of the unprocessed precursor] CRC64: B516B2A6989E620F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
METKIKKQRS LYIPYAGPVL LEFPLLNKGS AFSIEERRNF NLLGLLPEVV ESIEEQAERA 

        70         80         90        100        110        120 
WIQYQGFKTE IDKHIYLRNI QDTNETLFYR LVQNHLDEMM PVIYTPTVGA ACERFSEIYR 

       130        140        150        160        170        180 
RARGVFISYQ NRHNMDDILQ NVPNHNIKVI VVTDGERILG LGDQGIGGMG IPIGKLSLYT 

       190        200        210        220        230        240 
ACGGISPAYT LPVVLDVGTN NQQLLNDPLY MGWRNPRITD DEYYEFVDEF IQAVKQRWPD 

       250        260        270        280        290        300 
VLLQFEDFAQ KNAMPLLNRY RDEICSFNDD IQGTAAVTVG TLIAASRAAG SQLSEQKIVF 

       310        320        330        340        350        360 
LGAGSAGCGI AEQIIAQTQR EGLSEEAARQ KVFMVDRFGL LTDQMPNLLS FQTKLVQKRE 

       370        380        390        400        410        420 
NLQHWDSESE VLSLLDVVRN VKPDILIGVS GQTGLFTEEI IREMHKHCPR PIVMPLSNPT 

       430        440        450        460        470        480 
SRVEATPQDI IAWTEGNALV ATGSPFAPVA WKDKIYPIAQ CNNAYIFPGI GLGVIASGAS 

       490        500        510        520        530        540 
RITDEMLMSA SETLAKYSPL VLNGEGLVLP ELKDIQTVSR AIAFAVGKMA QQQGVAVKTS 

       550        560 
AEALQQAIDE NFWQAEYRDY RRTSI
A8AGN6 in FASTA format

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