FUNCTION: The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity).
CATALYTIC ACTIVITY: 2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO₂.
COFACTOR: Thiamine pyrophosphate (By similarity).
SUBUNIT: Homodimer (By similarity).
SIMILARITY: Belongs to the alpha-ketoglutarate dehydrogenase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000764; ABS21292.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001374287.1; -.

3D structure databases

ModBase

A7GMD4.

Ontologies

GO:0004591;	Molecular function: oxoglutarate dehydrogenase (succinyl-transferring) activity (inferred from electronic annotation from HAMAP).
GO:0030976;	Molecular function: thiamin pyrophosphate binding (inferred from electronic annotation from HAMAP).
GO:0006096;	Biological process: glycolysis (inferred from electronic annotation from HAMAP).
GO:0055114;	Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.

Family and domain databases

HAMAP

MF_01169; -; 1.
PBIL [Tree]

InterPro

IPR011603; 2oxoglutarate_DHase_E1.
IPR001017; DHase_E1.
IPR005475; Transketo_Cen_R.
Graphical view of domain structure.

PANTHER

PTHR23152; 2oxoglutarate_DH_E1; 1.

Pfam

PF00676; E1_dh; 1.
PF02779; Transket_pyr; 1.
Pfam graphical view of domain structure.

PIRSF

PIRSF000157; Oxoglu_dh_E1; 1.

TIGRFAMs

TIGR00239; 2oxo_dh_E1; 1.

ProtoNet

A7GMD4.

Genome annotation databases

GeneID

5346526; -.

GenomeReviews

CP000764_GR; Bcer98_0961.

KEGG

bcy:Bcer98_0961; -.

CMR

A7GMD4; Bcer98_0961.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

Complete proteome; Glycolysis; Oxidoreductase; Thiamine pyrophosphate.

Features

Feature table viewer

`Key`	`From To`	`Length`		`Description`	`FTId`
`CHAIN`	`1 958`	`958`		`2-oxoglutarate dehydrogenase E1 component.`	`PRO_1000085384`

Sequence information

Length: 958 AA [This is the length of the unprocessed precursor]

Molecular weight: 107259 Da [This is the MW of the unprocessed precursor]

CRC64: C3D676435F9C4694 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MTRKNTATNP WAKFHGPNLG YVIEQYDRYM TNEGSVDPEL QELFETFGAP TFQVDVVTGD 

        70         80         90        100        110        120 
NKETNFSPQS TGNIETILKA VQVVENIRSF GHLSAHINPM EEPHDGQSLI ETMMRELNDV 

       130        140        150        160        170        180 
DLKAIPAKTV WPDAPNDVHT ALDAIHRLKD VYTKSLAYEF SHIQDSEERT WLHQMVESNS 

       190        200        210        220        230        240 
LRQPLSNQKR TALLKRLTAV EGFEQFLHKT FVGQKRFSIE GVDMLVPVLD EMIAEGAKAG 

       250        260        270        280        290        300 
VEDVMIGMAH RGRLSVLAHV LEKPYSHMFA EFKHATIQSD DKTNHNAGWT GDVKYHLGRE 

       310        320        330        340        350        360 
QVVGNETVRT RVTLANNPSH LEFVNPVVEG YARAAQENRK KAGYPEQDSS KSFVILVHGD 

       370        380        390        400        410        420 
AAFPGQGIVS ETLNLSRLNA YQTGGTIHII ANNTIGFTTD SYDSRSTRYS SDLAKGFDIP 

       430        440        450        460        470        480 
IVHVNADDPE ACLAAANLAI QYRLRFKKDI LIDLIGYRRY GHNEMDDPAV TQPQVYKKIK 

       490        500        510        520        530        540 
NHPTVRAIYA EQLKAEGVLS SDEVETITQF TQEQLKAEYA QVPPADTSEA AIHVKVPDVV 

       550        560        570        580        590        600 
ARGIQPIDTG LPLETLRAIN EGLLSWPEGF NVYPKVKKIL ERRRTALDAD GKVEWALAES 

       610        620        630        640        650        660 
LAFASILQEG TPIRLTGQDS QRGTFAQRHI VLHDTETNET YSPLHRLPNI NASFSVHNSP 

       670        680        690        700        710        720 
LSEAAVVGFE YGYNVFAPET LVMWEAQYGD FANTAQALFD QYVSSGRAKW GQKSGLVLLL 

       730        740        750        760        770        780 
PHGYEGQGPE HSSARPERFL QLAAENNWTV ANLTSAAQYF HILRRQASIL GTEAVRPLVI 

       790        800        810        820        830        840 
MTPKSLLRHP LTASTGSELS EGCFQPALEQ EKLGTKPTKV KRLIFTTGKM AIDLAAEIES 

       850        860        870        880        890        900 
GKHEYNLDEL HIVRIEQLYP FPAEKVQSII KRFKNLEEII WVQEEPRNMG AWHYMAPILF 

       910        920        930        940        950 
ELAGDKLKTG YIGRPDRSSP SGGDPHAHKA EQELIIAHAL DTNYNFRQDK QEIEVYSN

A7GMD4 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools