NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Copeland A., Lucas S., Lapidus A., Barry K., Glavina del Rio T., Dalin E., Tice H., Pitluck S., Clum A., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I., Sieprawska-Lupa M., Whitman W.B., Richardson P.;
"Complete sequence of Methanococcus maripaludis C7.";
Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.

Comments

FUNCTION: This protein seals, during DNA replication, DNA recombination and DNA repair, nicks in double-stranded DNA (By similarity).
CATALYTIC ACTIVITY: ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).
SIMILARITY: Belongs to the ATP-dependent DNA ligase family.

Copyright

Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.

Cross-references

Sequence databases

EMBL

CP000745; ABR65285.1; -; Genomic_DNA.

[EMBL / GenBank / DDBJ] [CoDingSequence]

RefSeq

YP_001329436.1; -.

3D structure databases

ModBase

A6VFQ9.

Ontologies

GO:0005524;	Molecular function: ATP binding (inferred from electronic annotation from HAMAP).
GO:0003677;	Molecular function: DNA binding (inferred from electronic annotation from InterPro).
GO:0003910;	Molecular function: DNA ligase (ATP) activity (inferred from electronic annotation from HAMAP).
GO:0007049;	Biological process: cell cycle (inferred from electronic annotation from UniProtKB-KW).
GO:0051301;	Biological process: cell division (inferred from electronic annotation from UniProtKB-KW).
GO:0006310;	Biological process: DNA recombination (inferred from electronic annotation from HAMAP).
GO:0006281;	Biological process: DNA repair (inferred from electronic annotation from HAMAP).
GO:0006260;	Biological process: DNA replication (inferred from electronic annotation from HAMAP).
QuickGo view.

Family and domain databases

HAMAP

MF_00407; -; 1.
PBIL [Tree]

InterPro

IPR000977; DNA_ligase.
IPR012309; DNA_ligase_A_C.
IPR012310; DNA_ligase_A_M.
IPR012308; DNA_ligase_A_N.
IPR016059; DNA_ligase_CS.
IPR012340; NA-bd_OB-fold.
Graphical view of domain structure.

Gene3D

G3DSA:2.40.50.140; OB_NA_bd_sub; 1.

Pfam

PF04679; DNA_ligase_A_C; 1.
PF01068; DNA_ligase_A_M; 1.
PF04675; DNA_ligase_A_N; 1.
Pfam graphical view of domain structure.

TIGRFAMs

TIGR00574; dnl1; 1.

PROSITE

PS00697; DNA_LIGASE_A1; 1.
PS00333; DNA_LIGASE_A2; 1.
PS50160; DNA_LIGASE_A3; 1.
PROSITE graphical view of domain structure (profiles).

ProtoNet

A6VFQ9.

Genome annotation databases

GeneID

5328957; -.

GenomeReviews

CP000745_GR; MmarC7_0215.

KEGG

mmz:MmarC7_0215; -.

CMR

A6VFQ9; MmarC7_0215.

Other

UniRef

View cluster of proteins with at least 50% / 90% / 100% identity.

Keywords

ATP-binding; Cell cycle; Cell division; Complete proteome; DNA damage; DNA recombination; DNA repair; DNA replication; Ligase; Nucleotide-binding.

Features

Feature table viewer

`Key`	`From To`	`Length`	`Description`	`FTId`
`CHAIN`	`1 573`	`573`	`DNA ligase.`	`PRO_1000049871`
`ACT_SITE`	`252 252`		`N6-AMP-lysine intermediate (By similarity).`

Sequence information

Length: 573 AA [This is the length of the unprocessed precursor]

Molecular weight: 65814 Da [This is the MW of the unprocessed precursor]

CRC64: 5B28D05EF1F134E1 [This is a checksum on the sequence]

        10         20         30         40         50         60 
MLFIDFCKIL DKIEKTTKRL EKTDYFVELI DFIKTNGKPE NLKQVSQITI GRVFAEFENK 

        70         80         90        100        110        120 
EIGIGPNLLL EAVKTTGISE KDLKSKIKET GDIGIAVENL SSNIKQVSLF SQALTLEEVY 

       130        140        150        160        170        180 
STLKKLSEIE GNSSQKKKTR IISNLLILAT PVESRYISRL ILEDMRIGMN IPTILASFSN 

       190        200        210        220        230        240 
YFNINKETVE KIYAVTNDIG LLGEKLISGS NIENDSELQL KVFRPIKPML AQLTPSIEAA 

       250        260        270        280        290        300 
IIETKMPQFE TKYDGARVQV HKSDGNVKIY SRRLENITNS VPELVEEIKK IDIDNIILEG 

       310        320        330        340        350        360 
ECVAMDLSSG KPRPFQDILR RFRRKYDIDK MAEKIALRIY FFDVLYYEKG LIDTPLKDRR 

       370        380        390        400        410        420 
EILEKLFGTN NWDTELSKIE KEIFSNKMLF SSFKLNSDDP ILAKEFFNWS LSIGHEGIMI 

       430        440        450        460        470        480 
KNPDAPYTPG SRVKTMYKVK PTLENLDVVV TRAKIGMGKR KDWYGSYEIS VKDYEDNLHV 

       490        500        510        520        530        540 
IGNVGTGLTE DDLEKLTKIV NEIKIEDLGE EVILEPKIVL EVTYEEIQTS EKYEMGYALR 

       550        560        570 
FPRVVQIRED KSINDINTLD DVKKIYEIER NRK

A6VFQ9 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
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	BLAST submission on ExPASy/SIB or at NCBI (USA)		Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
	ScanProsite, MotifScan		Submit a homology modeling request to SWISS-MODEL
	NPSA Sequence analysis tools