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UniProtKB/Swiss-Prot entry A4IQV4

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name GCSPA_GEOTN
Primary accession number A4IQV4
Secondary accession numbers None
Integrated into Swiss-Prot on January 15, 2008
Sequence was last modified on May 1, 2007 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 15)
Name and origin of the protein
Protein name Probable glycine dehydrogenase [decarboxylating] subunit 1
Synonyms EC 1.4.4.2
Glycine decarboxylase subunit 1
Glycine cleavage system P-protein subunit 1
Gene name
Name: gcvPA
OrderedLocusNames: GTNG_2363
From
Geobacillus thermodenitrificans (strain NG80-2) [TaxID: 420246] [HAMAP proteome]
Taxonomy Bacteria; Firmicutes; Bacillales; Bacillaceae; Geobacillus.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
DOI=10.1073/pnas.0609650104; PubMed=17372208 [NCBI, ExPASy, EBI, Israel, Japan]
Feng L., Wang W., Cheng J., Ren Y., Zhao G., Gao C., Tang Y., Liu X., Han W., Peng X., Liu R., Wang L.;
"Genome and proteome of long-chain alkane degrading Geobacillus thermodenitrificans NG80-2 isolated from a deep-subsurface oil reservoir.";
Proc. Natl. Acad. Sci. U.S.A. 104:5602-5607(2007).
Comments
  • FUNCTION: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity).
  • CATALYTIC ACTIVITY: Glycine + H-protein-lipoyllysine = H-protein-S-aminomethyldihydrolipoyllysine + CO2.
  • SUBUNIT: The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is an heterodimer of two subunits (By similarity).
  • SIMILARITY: Belongs to the gcvP family. N-terminal subunit subfamily.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
CP000557; ABO67708.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001126453.1; -.
3D structure databases
ModBase A4IQV4.
Ontologies
GO
GO:0004375; Molecular function: glycine dehydrogenase (decarboxylating) activity (inferred from electronic annotation from InterPro).
GO:0030170; Molecular function: pyridoxal phosphate binding (inferred from electronic annotation from InterPro).
GO:0019464; Biological process: glycine decarboxylation via glycine cleavage system (inferred from electronic annotation from HAMAP).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
HAMAP MF_00712; -; 1.
PBIL [Tree]
InterPro IPR003437; GDC-P.
IPR015421; PyrdxlP-dep_Trfase_major_sub1.
Graphical view of domain structure.
Gene3D G3DSA:3.40.640.10; PyrdxlP-dep_Trfase_major_sub1; 1.
PANTHER PTHR11773; GDC-P; 1.
Pfam PF02347; GDC-P; 1.
Pfam graphical view of domain structure.
ProtoNet A4IQV4.
Genome annotation databases
GeneID 4967289; -.
GenomeReviews CP000557_GR; GTNG_2363.
KEGG gtn:GTNG_2363; -.
NMPDR fig|420246.5.peg.2269; -.
CMR A4IQV4; GTNG_2363.
Other
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; Oxidoreductase.
Features
SEVIEWER logo Feature table viewer
KeyFrom To Length Description FTId
CHAIN   1   448  448     Probable glycine dehydrogenase [decarboxylating] subunit 1. PRO_1000045657
Sequence information
Length: 448 AA [This is the length of the unprocessed precursor] Molecular weight: 49693 Da [This is the MW of the unprocessed precursor] CRC64: 918C47A42E927F7F [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MLHRYLPMTE EDKQEMLKTI GVASIDELFA DIPEQVRFRG ELNVKRAKSE PELWKELSAL 

        70         80         90        100        110        120 
ADKNANARQY VSFLGAGVYD HYIPAVVDHV LMRSEFYTAY TPYQPEISQG ELQAIFEFQT 

       130        140        150        160        170        180 
MVCELTGMDV ANSSMYDGGT ALAEAVLLSA AHTKRRKVLI SNAVHPQYRE VVRTYANGQR 

       190        200        210        220        230        240 
LEVKEIPYNG GVTDLEVLAA EMGDDVACVV IQYPNFFGQI EPLKAIEPLV HEKKSLFVVA 

       250        260        270        280        290        300 
SNPLALGVLT PPGEFGADIV VGDMQPFGIP MQFGGPHCGY FAVKAPLMRK IPGRLVGQTT 

       310        320        330        340        350        360 
DEEGRRGFVL TLQAREQHIR RDKATSNICS NQALNALAAS VALSALGKRG VKEMATMNMQ 

       370        380        390        400        410        420 
KAHYAKSELQ KRGLLSPFAG PFFNEFVIRL NQPVDDVNAR LRQKGIIGGY NLGFDYPELA 

       430        440 
NHMLVAVTEL RTKEEIDRFV NELGDGHA
A4IQV4 in FASTA format

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