Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

References

[1]	MAPPING ON GEL Anderson N.L. Personal communication (1993)

Comments

SUBUNIT: HOMOPENTAMER

2D PAGE maps for identified proteins

How to interpret a protein

PLASMA_HUMAN {Plasma}
Homo sapiens (Human)
Tissue: Plasma

map experimental info
protein estimated location

PLASMA_HUMAN

MAP LOCATIONS:

SPOT 2D-0005EI:

pI=5.12; Mw=23760

NORMAL LEVEL:
2-5 MG/L [1].

PATHOLOGICAL LEVEL:
INCREASED DURING ACUTE AND CHRONIC BACTERIAL INFECTIONS, CELL NECROSIS, CHRONIC RENAL FAILURE, HODGKINS DISEASE AND ACTIVE RHEUMATOID ARTHRITIS [1].

MAPPING (identification):
IMMUNOBLOTTING [1].

Copyright

This SWISS-2DPAGE entry is copyright the Swiss Institute of Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified and this statement is not removed. Usage by and for commercial entities requires a license agreement (See http://www.expasy.org/ch2d/license.html or send email to license@isb-sib.ch).

Cross-references

DOSAC-COBS-2DPAGE

P02741; CRP_HUMAN.

UniProtKB/Swiss-Prot

P02741; CRP_HUMAN.

2D PAGE maps for unidentified proteins

How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed.

Arabidopsis thaliana
(Mouse-ear cress)

Arabidopsis thaliana

Dictyostelium discoideum
(Slime mold)

Dictyostelium discoideum

Escherichia coli

Escherichia coli	Escherichia coli DIGE (4.5-6.5)	Escherichia coli(4-5)
Escherichia coli(4.5-5.5)	Escherichia coli(5-6)	Escherichia coli(5.5-6.7)
Escherichia coli(6-11)	Escherichia coli(6-9)

Homo sapiens
(Human)

Colorectal epithelia cells	Cerebrospinal Fluid	Colorectal adenocarcinoma cell line (DL-1)
Erythroleukemia Cell	HepG2 Secreted Proteins	HepG2
Promyelocytic leukemia cells	Kidney	Liver
Lymphocytes	Lymphoma	Soluble nuclear proteins and matrix from liver tissue
SDS-PAGE of nucleolar proteins from Human HeLa cells	2D-PAGE of nucleolar proteins from Human HeLa cells	Platelet
Red blood cells	Macrophage Like Cell Line

Mus musculus
(Mouse)

Brown adipose tissue	Pancreatic islet cells	Liver
Gastrocnemius muscle	Soluble nuclear proteins and matrix from liver tissue	White adipose tissue

Saccharomyces cerevisiae
(Baker's yeast)

Saccharomyces cerevisiae

Staphylococcus aureus
(strain N315)

Staphylococcus aureus

External data extracted from UniProtKB/Swiss-Prot
Extracted from UniProtKB/Swiss-Prot, release: 54.70
Entry name	CRP_HUMAN
Primary accession number	P02741
Secondary accession number(s)	Q08AK3 Q8WW75
Name and origin of the protein
Description	C-reactive protein precursor [Contains: C-reactive protein(1-205)]
Gene name	Name=CRP Synonyms=PTX1
Keywords	3D-structure; Acute phase; Alternative splicing; Calcium; Direct protein sequencing; Metal-binding; Pyrrolidone carboxylic acid; Secreted; Signal.
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL	M11880; AAB59526.1; -; Genomic_DNA.
EMBL	M11725; AAA52075.1; -; Genomic_DNA.
EMBL	X56692; CAA40020.1; -; mRNA.
EMBL	X56214; CAA39671.1; -; mRNA.
EMBL	AF442818; AAL48218.2; -; Genomic_DNA.
EMBL	AF449713; AAL40835.1; -; Genomic_DNA.
EMBL	AL445528; CAH73654.1; -; Genomic_DNA.
EMBL	AL445528; CAH73656.1; -; Genomic_DNA.
EMBL	BC020766; AAH20766.1; -; mRNA.
EMBL	BC125135; AAI25136.1; -; mRNA.
EMBL	M35163; AAA52076.1; -; mRNA.
EMBL	K00518; AAA52074.1; -; mRNA.
PIR	A24515; CJHU.
RefSeq	NP_000558.2; -.
UniGene	Hs.695960; -.
UniGene	Hs.76452; -.
PDB	1B09; X-ray; 2.50 A; A/B/C/D/E=19-224.
PDB	1CRV; Model; -; A/B/C/D/E=19-224.
PDB	1GNH; X-ray; 3.00 A; A/B/C/D/E/F/G/H/I/J=19-224.
PDB	1LJ7; X-ray; 3.15 A; A/B/C/D/E/F/G/H/I/J=19-224.
PDBsum	1B09; -.
PDBsum	1CRV; -.
PDBsum	1GNH; -.
PDBsum	1LJ7; -.
IntAct	P02741; -.
SWISS-2DPAGE	P02741; HUMAN.
DOSAC-COBS-2DPAGE	P02741; HUMAN.
PeptideAtlas	P02741; -.
Ensembl	ENSG00000132693; Homo sapiens.
GeneID	1401; -.
KEGG	hsa:1401; -.
H-InvDB	HIX0028720; -.
HGNC	HGNC:2367; CRP.
HPA	CAB005036; -.
MIM	123260; gene.
PharmGKB	PA120; -.
LinkHub	P02741; -.
ArrayExpress	P02741; -.
CleanEx	HS_CRP; -.
GermOnline	ENSG00000132693; Homo sapiens.
GO	GO:0005576; C:extracellular region; NAS:UniProtKB.
GO	GO:0005515; F:protein binding; IPI:IntAct.
GO	GO:0006954; P:inflammatory response; TAS:ProtInc.
InterPro	IPR013320; ConA_like_subgrp.
InterPro	IPR001759; Pentaxin.
Gene3D	G3DSA:2.60.120.200; ConA_like_subgrp; 1.
Pfam	PF00354; Pentaxin; 1.
PRINTS	PR00895; PENTAXIN.
ProDom	PD002153; Pentaxin; 1.
SMART	SM00159; PTX; 1.
PROSITE	PS00289; PENTAXIN; 1.

Database constructed and maintained by Christine Hoogland, using the Make2D-DB II package (ver. 2.50.2) from the World-2DPAGE Constellation of the ExPASy web server

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