HPI The UniProtKB/Swiss-Prot Human Proteome Initiative

The first draft of the complete human proteome is available in UniProtKB/Swiss-Prot.

The Human Proteome Initiative (HPI) aims to annotate all known human protein sequences and their mammalian orthologs, according to the quality standards of UniProtKB/Swiss-Prot. This goal has been partially reached as of UniProt release 14.1 of 2-Sep-2008, since a manually annotated representation of all the currently known human protein-coding genes has been made publicly available on our website. In addition to accurate sequences, we offer, for each characterized protein, a wealth of information that includes the description of its function, domain structure, subcellular location, similarities to other proteins, etc.

Although as complete as currently possible, the human protein set we provide is still imperfect, it will have to be reviewed and updated with future research results. We will also create entries for newly discovered human proteins, increase the number of splice variants, explore the full range of post-translational modifications (PTMs) and continue to build a comprehensive view of protein variation in the human population.

In the annotation process, special emphasis is given to the generation of high levels of protein diversity. These are mainly generated by alternative splicing and post-translational modifications (PTMs). Polymorphisms are also reported as they provide links between genotypes and diseases as well as other complex phenotypes. Numerous cross-references are made to specialized databases, such as OMIM, HGNC and H-InvDB, as well as to the PDB/RCSB 3D-structure database.

Chromosome pages