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HAMAP: Ehrlichia chaffeensis (strain Arkansas) complete proteome

General information

Species:  Ehrlichia chaffeensis (strain Arkansas)
Species code: EHRCR
Taxonomy: Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales; Anaplasmataceae; Ehrlichia (TaxID: 205920) [NEWT/ NCBI]
Description: Ehrlichia chaffeensis (strain Arkansas) is an intracellular vector-borne pathogen that causes human ehrlichiosis. It depends on hematophagous ticks as a vector and wild mammals as a reservoir host. It has been most commonly identified in the Lone Star tick (Amblyomma americanum), with white-tailed deer considered to be the major reservoir. E. chaffeensis is the causative agent of human monocytic ehrlichiosis (HME), a disease that was discovered in 1986. It is a systemic disease that is indistinguishable from human granulocytic ehrlichiosis (HGA) caused by Anaplasma phagocytophilum. It replicates in monocytes/macrophages. The genome of E. chaffeensis is made up of a singular chromosome. Despite the limited ability of Rickettsiales to synthesize amino acids, E.chaffeensis seems to be able to synthesize arginine and lysine.
Properties: Presence of flagella: No
Human pathogen: Yes
Interaction: Animal pathogen in Mammalia
Number of membranes: 2
Number of inteins:0
Statistics: Number of EHRCR entries in the UniProt Knowledgebase: 1099 (185 in UniProtKB/Swiss-Prot + 914 in UniProtKB/TrEMBL)


Genome(s) sequenced

Strain:    Arkansas
Genome structure:
Chromosome EMBL accession number CP000236 (circular; 1,176,248 bp) (download entry) (download Genome Reviews).
Reference(s):
[1] PubMed=16482227; [ NCBI , EBI , Israel , Japan ]
Dunning Hotopp J.C., Lin M., Madupu R., Crabtree J., Angiuoli S.V., Eisen J.A., Seshadri R., Ren Q., Wu M., Utterback T.R., Smith S., Lewis M., Khouri H., Zhang C., Niu H., Lin Q., Ohashi N., Zhi N., Nelson W.C., Brinkac L.M., Dodson R.J., Rosovitz M.J., Sundaram J.P., Daugherty S.C., Davidsen T., Durkin A.S., Gwinn M.L., Haft D.H., Selengut J.D., Sullivan S.A., Zafar N., Zhou L., Benahmed F., Forberger H., Halpin R., Mulligan S., Robinson J., White O., Rikihisa Y., Tettelin H. ;
"Comparative genomics of emerging human ehrlichiosis agents.";
PLoS Genet. 2:208-222(2006).
Web links:
Official genome site(s):
http://cmr.tigr.org/tigr-scripts/CMR/GenomePage.cgi?org_search=&org=gech
Other web sites:
CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Ehrlichia&GLspecies=chaffeensis&GLsupStrain=Arkansas
Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid205920%5Borgn%5D
GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Echa_ARKANSAS
PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=start_method&Db=p3_p325_Ehr_chaff
 EBI Proteome Analysis page



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