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| HAMAP: Escherichia coli O139:H28 (strain E24377A / ETEC) complete proteome |
General information
Species: Escherichia coli O139:H28 (strain E24377A / ETEC)
| Species code: | ECO24 |
| Taxonomy: | Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacteriales; Enterobacteriaceae; Escherichia (TaxID: 331111) [NEWT/ NCBI] |
| Description: | Escherichia coli is a Gram-negative straight rod, which either uses peritrichous flagella for mobility or is nonmotile. It is a facultatively anaerobic chemoorganotroph capable of both respiratory and fermentative metabolism. E.coli serves a useful function in the body by suppressing the growth of harmful bacterial species and by synthesising appreciable amounts of vitamins. It is an important component of the biosphere. It colonizes the lower gut of animals and survives when released to the natural environment, allowing widespread dissemination to new hosts. Pathogenic E.coli strains are responsible for infection of the enteric, urinary, pulmonary and nervous systems. Comparison of 20 E.coli/Shigella strains shows the core genome to be about 2000 genes while the pan-genome has over 18,000 genes. There are multiple, striking integration hotspots that are conserved across the genomes, corresponding to regions of abundant and parallel insertions and deletions of genetic material. Escherichia coli E24377A is an enterotoxigenic E. coli (ETEC) isolate, ETEC being the leading cause of traveler's diarrhea, characterized by a large volume of watery diarrhea. It belongs to phylogroup B1. ETEC primarily colonizes the small intestine by way of the colonization factor antigen (CFA) pili; E. coli E24377A has been shown to contain CFA pili types CS1 and CS3. Two additional toxins are thought to be responsible for the virulence, a heat stable and a heat labile enterotoxin. Other virulence factors include serotype O139:H28 and potential factors encoded on 6 uncharacterized plasmids. Approximately 4% of the genome is composed of insertion sequences. This strain is probably capable of utilizing propanediol as a sole carbon source. |
| Properties: |
Presence of flagella:
Yes? Human pathogen: Yes Interaction: Animal pathogen in Mammalia Number of membranes: 2 Number of inteins:0 |
| Statistics: | Number of ECO24 entries in the UniProt Knowledgebase: 4915 (829 in UniProtKB/Swiss-Prot + 4086 in UniProtKB/TrEMBL) |
Genome(s) sequenced
Strain: E24377A / ETEC
| Genome structure: |
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Tools
- Genome Proximity Viewer: This program displays the genes that are found in the genomic environment of a selected locus.
- Perform a BLAST search against all proteins from this proteome
- Download a file by FTP containing all UniProt Knowledgebase entries of this proteome
- Retrieve set of characterized or identified proteins for this proteome
- Retrieve set of proteins with 3D structure for this proteome