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NiceZyme View of ENZYME: EC 2.7.11.13

Accepted Name
Protein kinase C.
Alternative Name(s)
Calcium-dependent protein kinase C.
Calcium-independent protein kinase C.
Calcium/phospholipid dependent protein kinase.
CPKC.
NPKC.
PKC.
Reaction catalysed
ATP + a protein <=> ADP + a phosphoprotein
Comment(s)
  • A family of serine- and threonine-specific protein kinases that depend on lipids for activity.
  • They can be activated by calcium but have a requirement for the second messenger diacylglycerol.
  • Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways.
  • Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters.
Cross-references
PROSITEPDOC00100
BRENDA2.7.11.13
EC2PDB2.7.11.13
PRIAM enzyme-specific profiles2.7.11.13
KEGG Ligand Database for Enzyme Nomenclature2.7.11.13
IUBMB Enzyme Nomenclature2.7.11.13
IntEnz2.7.11.13
MEDLINEFind literature relating to 2.7.11.13
MetaCyc2.7.11.13
UniProtKB/Swiss-Prot
A8XWC4, DKF1_CAEBR;  Q9XUJ7, DKF1_CAEEL;  A8XQD5, DKF2_CAEBR;  
O45818, DKF2_CAEEL;  P34885, KPC1B_CAEEL;  Q16974, KPC1_APLCA;  
Q00078, KPC1_ASPNG;  P34722, KPC1_CAEEL;  P43057, KPC1_CANAL;  
O42632, KPC1_COCHE;  P05130, KPC1_DROME;  Q25378, KPC1_LYTPI;  
P87253, KPC1_NEUCR;  Q99014, KPC1_TRIRE;  P24583, KPC1_YEAST;  
Q16975, KPC2_APLCA;  P90980, KPC2_CAEEL;  P13677, KPC2_DROME;  
A8WUG4, KPC3_CAEBR;  Q19266, KPC3_CAEEL;  P13678, KPC3_DROME;  
P83099, KPC4_DROME;  P04409, KPCA_BOVIN;  P17252, KPCA_HUMAN;  
P20444, KPCA_MOUSE;  P10102, KPCA_RABIT;  P05696, KPCA_RAT;  
P05126, KPCB_BOVIN;  P05771, KPCB_HUMAN;  P68404, KPCB_MOUSE;  
P05772, KPCB_RABIT;  P68403, KPCB_RAT;  Q15139, KPCD1_HUMAN;  
Q62101, KPCD1_MOUSE;  Q9WTQ1, KPCD1_RAT;  Q9BZL6, KPCD2_HUMAN;  
Q8BZ03, KPCD2_MOUSE;  Q5XIS9, KPCD2_RAT;  O94806, KPCD3_HUMAN;  
Q8K1Y2, KPCD3_MOUSE;  Q5PU49, KPCD_CANFA;  Q05655, KPCD_HUMAN;  
P28867, KPCD_MOUSE;  P09215, KPCD_RAT;  Q02156, KPCE_HUMAN;  
P16054, KPCE_MOUSE;  P10830, KPCE_RABIT;  P09216, KPCE_RAT;  
P05128, KPCG_BOVIN;  P05129, KPCG_HUMAN;  Q4R4U2, KPCG_MACFA;  
P63318, KPCG_MOUSE;  P10829, KPCG_RABIT;  P63319, KPCG_RAT;  
Q90XF2, KPCI_DANRE;  P41743, KPCI_HUMAN;  Q62074, KPCI_MOUSE;  
Q5R4K9, KPCI_PONAB;  P24723, KPCL_HUMAN;  P23298, KPCL_MOUSE;  
Q64617, KPCL_RAT;  Q04759, KPCT_HUMAN;  Q02111, KPCT_MOUSE;  
Q9WTQ0, KPCT_RAT;  Q05513, KPCZ_HUMAN;  Q02956, KPCZ_MOUSE;  
O19111, KPCZ_RABIT;  P09217, KPCZ_RAT;  P36582, PCK1_SCHPO;  
P36583, PCK2_SCHPO;  Q16512, PKN1_HUMAN;  P70268, PKN1_MOUSE;  
Q63433, PKN1_RAT;  Q16513, PKN2_HUMAN;  Q8BWW9, PKN2_MOUSE;  
O08874, PKN2_RAT;  Q6P5Z2, PKN3_HUMAN;  Q8K045, PKN3_MOUSE;  

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