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NiceZyme View of ENZYME: EC 1.2.1.19

Accepted Name
Aminobutyraldehyde dehydrogenase.
Alternative Name(s)
1-pyrroline dehydrogenase.
4-aminobutanal dehydrogenase.
ABALDH.
Gamma-guanidinobutyraldehyde dehydrogenase.
Reaction catalysed
4-aminobutanal + NAD(+) + H(2)O <=> 4-aminobutanoate + NADH
Comment(s)
  • The enzyme from some species exhibits broad substrate specificity and has a marked preference for straight-chain aldehydes (up to 7 carbon atoms) as substrates.
  • The plant enzyme also acts on 4-guanidinobutanal (cf. EC 1.2.1.54).
  • As 1-pyrroline and 4-aminobutanal are in equilibrium and can be interconverted spontaneously, 1-pyrroline may act as the starting substrate.
  • Formerly EC 1.5.1.35.
Cross-references
Biochemical Pathways; map number(s)F7 ; H6
PROSITEPDOC00068
BRENDA1.2.1.19
EC2PDB1.2.1.19
PRIAM enzyme-specific profiles1.2.1.19
KEGG Ligand Database for Enzyme Nomenclature1.2.1.19
IUBMB Enzyme Nomenclature1.2.1.19
IntEnz1.2.1.19
MEDLINEFind literature relating to 1.2.1.19
MetaCyc1.2.1.19
UniProtKB/Swiss-Prot
A8AGJ9, ABDH_CITK8;  A7ZLN7, ABDH_ECO24;  B7URJ0, ABDH_ECO27;  
B7MMS8, ABDH_ECO45;  B7L6F9, ABDH_ECO55;  Q8X9W5, ABDH_ECO57;  
B5Z0W0, ABDH_ECO5E;  B7MUN0, ABDH_ECO81;  B7LZ33, ABDH_ECO8A;  
C4ZVI3, ABDH_ECOBW;  B1XDF5, ABDH_ECODH;  A8A002, ABDH_ECOHS;  
A1AB46, ABDH_ECOK1;  Q0THX6, ABDH_ECOL5;  Q8FHK7, ABDH_ECOL6;  
B1IS15, ABDH_ECOLC;  P77674, ABDH_ECOLI;  B7N4K1, ABDH_ECOLU;  
B6IAI9, ABDH_ECOSE;  B1LFH3, ABDH_ECOSM;  Q1RBX3, ABDH_ECOUT;  
A4WAR9, ABDH_ENT38;  Q6D6Y7, ABDH_ERWCT;  B7LR95, ABDH_ESCF3;  
C6DD82, ABDH_PECCP;  A9MQY3, ABDH_SALAR;  Q57P61, ABDH_SALCH;  
Q5PHV8, ABDH_SALPA;  A9MYQ4, ABDH_SALPB;  C0Q4N4, ABDH_SALPC;  
Q8Z747, ABDH_SALTI;  Q8ZPC9, ABDH_SALTY;  A8GHZ8, ABDH_SERP5;  
Q32FQ5, ABDH_SHIDS;  Q0T431, ABDH_SHIF8;  Q83R90, ABDH_SHIFL;  
Q3Z1H6, ABDH_SHISS;  P49189, AL9A1_HUMAN;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.2.1.-
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