| Official Name |
|---|
| Tryptophan 5-monooxygenase.
|
| Alternative Name(s) |
|---|
| Indoleacetic acid-5-hydroxylase. |
| L-tryptophan hydroxylase. |
| Tryptophan 5-hydroxylase. |
| Tryptophan hydroxylase. |
| Reaction catalysed |
|---|
| L-tryptophan + tetrahydrobiopterin + O(2) <=> 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin |
| Cofactor(s) |
|---|
| Iron.
|
| Comment(s) |
|---|
- Activated by phosphorylation, catalyzed by a Ca(2+)-activated protein
kinase.
- The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7-
dihydrobiopterin, both spontaneously and by the action of
EC 4.2.1.96.
- The 6,7-dihydrobiopterin can be enzymically reduced back to
tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the
more stable compound 7,8-dihydrobiopterin.
|
| Cross-references |
|---|
| Biochemical Pathways; map number(s) | H2 ; U4 |
| PROSITE | PDOC00316 |
| BRENDA | 1.14.16.4 |
| PUMA2 | 1.14.16.4 |
| PRIAM enzyme-specific profiles | 1.14.16.4 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.14.16.4 |
| IUBMB Enzyme Nomenclature | 1.14.16.4 |
| IntEnz | 1.14.16.4 |
| MEDLINE | Find literature relating to 1.14.16.4 |
| MetaCyc | 1.14.16.4 |
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