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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P00742: Variant p.Gly51Val

Coagulation factor X
Gene: F10
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Variant information Variant position: help 51 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Glycine (G) to Valine (V) at position 51 (G51V, p.Gly51Val). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from glycine (G) to medium size and hydrophobic (V) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -3 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In FA10D. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 51 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 488 The length of the canonical sequence.
Location on the sequence: help ANNILARVTRANSFLEEMKK G HLERECMEETCSYEEAREVF The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         ANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVF

Mouse                         ANNVLARTRRANSFFEEFKKGNLERECMEEICSYEEVREIF

Rat                           ANNVLQRIRRANSFFEEIKKGNLERECVEEICSFEEAREVF

Bovine                        AHRVLQRARRANSFLEEVKQGNLERECLEEACSLEEAREVF

Rabbit                        ANDVLARTRRANSFLEELKKGNLERECMEENCSYEEALEVF

Chicken                       ADKFLERTKRANSFLEEMKQGNIERECNEERCSKEEAREAF

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 41 – 488 Coagulation factor X
Chain 41 – 179 Factor X light chain
Domain 41 – 85 Gla
Modified residue 46 – 46 4-carboxyglutamate
Modified residue 47 – 47 4-carboxyglutamate
Modified residue 54 – 54 4-carboxyglutamate
Modified residue 56 – 56 4-carboxyglutamate
Modified residue 59 – 59 4-carboxyglutamate
Modified residue 60 – 60 4-carboxyglutamate
Modified residue 65 – 65 4-carboxyglutamate
Modified residue 66 – 66 4-carboxyglutamate
Modified residue 69 – 69 4-carboxyglutamate
Helix 47 – 57



Literature citations
Characterization of a homozygous Gly11Val mutation in the Gla domain of coagulation factor X.
Chafa O.; Tagzirt M.; Tapon-Bretaudiere J.; Reghis A.; Fischer A.M.; LeBonniec B.F.;
Thromb. Res. 124:144-148(2009)
Cited for: VARIANT FA10D VAL-51;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.