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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot O60260: Variant p.Ala371Thr

E3 ubiquitin-protein ligase parkin
Gene: PRKN
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Variant information Variant position: help 371 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help US The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Alanine (A) to Threonine (T) at position 371 (A371T, p.Ala371Thr). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from small size and hydrophobic (A) to medium size and polar (T) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 0 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In a patient with Parkinson disease; uncertain significance. Any additional useful information about the variant.


Sequence information Variant position: help 371 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 465 The length of the canonical sequence.
Location on the sequence: help TCEGGNGLGCGFAFCRECKE A YHEGECSAVFEASGTTTQAY The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         TCEGGNGLGCGFAFCRECKEAYHEGECSAVFEASGTTTQ---AY

Mouse                         TCEGGNGLGCGFVFCRDCKEAYHEGDCDSLLEPSGATSQ--

Rat                           TCEGGNGLGCGFVFCRDCKEAYHEGECDSMFEASGATSQ--

Drosophila                    TCQN----GCGYVFCRNCLQGYHIGEC--LPEGTGASATNS

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 465 E3 ubiquitin-protein ligase parkin
Zinc finger 313 – 377 IBR-type
Region 234 – 465 TRIAD supradomain
Binding site 352 – 352
Binding site 360 – 360
Binding site 365 – 365
Binding site 368 – 368
Binding site 373 – 373
Binding site 377 – 377
Cross 369 – 369 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)
Alternative sequence 298 – 465 Missing. In isoform 3.
Alternative sequence 369 – 465 Missing. In isoform 5.
Mutagenesis 365 – 365 C -> S. Impairs protein folding.



Literature citations
Evidence for the presence of full-length PARK2 mRNA and Parkin protein in human blood.
Kasap M.; Akpinar G.; Sazci A.; Idrisoglu H.A.; Vahaboglu H.;
Neurosci. Lett. 460:196-200(2009)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; SUBCELLULAR LOCATION; TISSUE SPECIFICITY; VARIANTS ARG-311 AND THR-371; IDENTIFICATION BY MASS SPECTROMETRY;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.