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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P07225: Variant p.Cys666Arg

Vitamin K-dependent protein S
Gene: PROS1
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Variant information Variant position: help 666 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Cysteine (C) to Arginine (R) at position 666 (C666R, p.Cys666Arg). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and polar (C) to large size and basic (R) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -3 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In THPH5. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 666 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 676 The length of the canonical sequence.
Location on the sequence: help GVQLDLDEAISKHNDIRAHS C PSVWKKTKNS The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 42 – 676 Vitamin K-dependent protein S
Domain 484 – 666 Laminin G-like 2
Disulfide bond 639 – 666



Literature citations
Identification of 19 protein S gene mutations in patients with phenotypic protein S deficiency and thrombosis.
Simmonds R.E.; Ireland H.; Kunz G.; Lane D.A.;
Blood 88:4195-4204(1996)
Cited for: VARIANTS THPH5 GLU-50; ALA-67; GLU-95; TYR-186; SER-241; PRO-324; ASP-381; SER-449 AND ARG-666; VARIANT PRO-501; Molecular basis for protein S hereditary deficiency: genetic defects observed in 118 patients with type I and type IIa deficiencies.
Borgel D.; Duchemin J.; Alhenc-Gelas M.; Matheron C.; Aiach M.; Gandrille S.;
J. Lab. Clin. Med. 128:218-227(1996)
Cited for: VARIANTS THPH5 SER-111; GLY-157; GLY-161; GLU-364; PRO-446; ARG-475; ALA-501; MET-508; CYS-515; PRO-525; ALA-532; TYR-568; ARG-575 AND ARG-666; VARIANT PRO-501; Five novel mutations of the protein S active gene (PROS 1) in 8 Norman families.
Duchemin J.; Borg J.-Y.; Borgel D.; Vasse M.; Leveque H.; Aiach M.; Gandrille S.;
Thromb. Haemost. 75:437-444(1996)
Cited for: VARIANTS THPH5 PRO-300 AND ARG-666; Genetic analysis, phenotypic diagnosis, and risk of venous thrombosis in families with inherited deficiencies of protein S.
Makris M.; Leach M.; Beauchamp N.J.; Daly M.E.; Cooper P.C.; Hampton K.K.; Bayliss P.; Peake I.R.; Miller G.J.; Preston F.E.;
Blood 95:1935-1941(2000)
Cited for: VARIANTS THPH5 TYR-166; GLY-247; THR-611; ARG-622 AND ARG-666;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.