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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P07225: Variant p.Met640Thr

Vitamin K-dependent protein S
Gene: PROS1
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Variant information Variant position: help 640 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Methionine (M) to Threonine (T) at position 640 (M640T, p.Met640Thr). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and hydrophobic (M) to medium size and polar (T) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In THPH5; does not affect protein levels; the mutant is secreted at lower levels compared to wild-type. Any additional useful information about the variant.


Sequence information Variant position: help 640 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 676 The length of the canonical sequence.
Location on the sequence: help GGLPDVPFSATPVNAFYNGC M EVNINGVQLDLDEAISKHND The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 42 – 676 Vitamin K-dependent protein S
Domain 484 – 666 Laminin G-like 2
Disulfide bond 639 – 666



Literature citations
Optimization of a simple and rapid single-strand conformation analysis for detection of mutations in the PROS1 gene: identification of seven novel mutations and three novel, apparently neutral, variants.
Espinosa-Parrilla Y.; Morell M.; Borrell M.; Souto J.C.; Fontcuberta J.; Estivill X.; Sala N.;
Hum. Mutat. 15:463-473(2000)
Cited for: VARIANTS THPH5 HIS-15; THR-640 AND LEU-667; VARIANTS SER-98; LYS-233 AND MET-559; Functional characterization of twelve natural PROS1 mutations associated with anticoagulant protein S deficiency.
Hurtado B.; Munoz X.; Mulero M.C.; Navarro G.; Domenech P.; Garcia de Frutos P.; Perez-Riba M.; Sala N.;
Haematologica 93:574-580(2008)
Cited for: CHARACTERIZATION OF VARIANTS THPH5 HIS-15 AND THR-640; CHARACTERIZATION OF VARIANT LYS-233;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.