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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q02928: Variant p.Ser353Gly

Cytochrome P450 4A11
Gene: CYP4A11
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Variant information Variant position: help 353 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Serine (S) to Glycine (G) at position 353 (S353G, p.Ser353Gly). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from small size and polar (S) to glycine (G) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 0 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Polymorphism: help CYP4A11v seems to be a rare allelic variant of CYP4A11, it seems to be unstable and not to metabolize lauric acid. Additional information on the polymorphism described.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 353 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 519 The length of the canonical sequence.
Location on the sequence: help ILYALATHPKHQERCREEIH S LLGDGASITWNHLDQMPYTT The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 5 – 519 Cytochrome P450 4A11



Literature citations
Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs.
Bell D.R.; Plant N.J.; Rider C.G.; Na L.; Brown S.; Ateitalla I.; Acharya S.K.; Davies M.H.; Elias E.E.; Jenkins N.A.; Gilbert D.J.; Copeland N.G.; Elcombe C.R.;
Biochem. J. 294:173-180(1993)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 317-457; VARIANTS GLY-353 AND SER-434; Highly polymorphic human CYP4A11 gene.
Cho B.H.; Park B.L.; Kim L.H.; Chung H.S.; Shin H.D.;
J. Hum. Genet. 50:259-263(2005)
Cited for: VARIANTS GLY-353 AND SER-434;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.