Expasy logo

UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P47712: Variant p.His442Gln

Cytosolic phospholipase A2
Gene: PLA2G4A
Feedback?
Variant information Variant position: help 442 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help US The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Histidine (H) to Glutamine (Q) at position 442 (H442Q, p.His442Gln). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Similar physico-chemical property. Both residues are medium size and polar. The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 0 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description: help In a breast cancer sample; somatic mutation. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 442 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 749 The length of the canonical sequence.
Location on the sequence: help ENITTKHIVSNDSSDSDDES H EPKGTENEDAGSDYQSDNQA The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         ENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQA

Mouse                         ENITAKHIVSNDSSDSDDEAQGPKGTENEEAEKEYQSDNQA

Rat                           ENITAKHIVSNDSSDSDDEAQGPKGTENEDAEREYQNDNQA

Bovine                        ENITAKHIVSNDSSDSDDESQGPKGTEHEEAEREYQNDNQA

Rabbit                        ENITAKHIVSNDSSDSDDESQEPKGTEGEDAEREYQNDHQA

Horse                         ENITAKHIVSNDSSDSDDESQEPKGTENEDAERDYQNDNQA

Chicken                       ENIRLKHLVSNDSSDSEDESQHPKGTENSEANEEYQNSSQE

Xenopus laevis                ENLKPKHILGNDSSDSDDEMQEPKGTENAKAEEEYLRNNQA

Xenopus tropicalis            ENLKPKHILGNDSSDSDDEMQEPKGTENSKAEEEYQRNNQA

Zebrafish                     EQIKPEHIVGDDSADNEEETQRG-GTESADAEDERQRHAQA

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 749 Cytosolic phospholipase A2
Domain 140 – 740 PLA2c
Region 409 – 457 Disordered
Compositional bias 420 – 452 Basic and acidic residues
Modified residue 434 – 434 Phosphoserine
Modified residue 435 – 435 Phosphoserine
Modified residue 437 – 437 Phosphoserine
Mutagenesis 437 – 437 S -> A. Reduces phospholipase A2 activity; when associated with A-454; A-505 and A-727.
Mutagenesis 454 – 454 S -> A. Reduces phospholipase A2 activity; when associated with A-437; A-505 and A-727.



Literature citations
The consensus coding sequences of human breast and colorectal cancers.
Sjoeblom T.; Jones S.; Wood L.D.; Parsons D.W.; Lin J.; Barber T.D.; Mandelker D.; Leary R.J.; Ptak J.; Silliman N.; Szabo S.; Buckhaults P.; Farrell C.; Meeh P.; Markowitz S.D.; Willis J.; Dawson D.; Willson J.K.V.; Gazdar A.F.; Hartigan J.; Wu L.; Liu C.; Parmigiani G.; Park B.H.; Bachman K.E.; Papadopoulos N.; Vogelstein B.; Kinzler K.W.; Velculescu V.E.;
Science 314:268-274(2006)
Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-442;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.