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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P32019: Variant p.Met745Thr

Type II inositol 1,4,5-trisphosphate 5-phosphatase
Gene: INPP5B
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Variant information Variant position: help 745 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Methionine (M) to Threonine (T) at position 745 (M745T, p.Met745Thr). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and hydrophobic (M) to medium size and polar (T) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 745 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 993 The length of the canonical sequence.
Location on the sequence: help RGFLLPDSDVEIDLELFVNK M TATKLNSGEDKIEDILVLHL The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human                         RGFLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILVLHL

Mouse                         KGFLLPDSHVEIELELFVNKSTATKLNSGKDTIEDILVLHL

Caenorhabditis elegans        ----------------LVGRFQVNEL---------------

Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 990 Type II inositol 1,4,5-trisphosphate 5-phosphatase
Region 669 – 782 ASH



Literature citations
Properties of type II inositol polyphosphate 5-phosphatase.
Jefferson A.B.; Majerus P.W.;
J. Biol. Chem. 270:9370-9377(1995)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2); FUNCTION; CATALYTIC ACTIVITY; SUBCELLULAR LOCATION; ISOPRENYLATION AT CYS-990; MUTAGENESIS OF CYS-990; VARIANT THR-745; The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4); VARIANT THR-745; Cloning and expression of human 75-kDa inositol polyphosphate-5-phosphatase.
Ross T.S.; Jefferson A.B.; Mitchell C.A.; Majerus P.W.;
J. Biol. Chem. 266:20283-20289(1991)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 284-954; PROTEIN SEQUENCE OF 321-339; VARIANT THR-745;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.