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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P63000: Variant p.Val182Glu

Ras-related C3 botulinum toxin substrate 1
Gene: RAC1
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Variant information Variant position: help 182 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Valine (V) to Glutamate (E) at position 182 (V182E, p.Val182Glu). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and hydrophobic (V) to medium size and acidic (E) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help -2 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 182 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 192 The length of the canonical sequence.
Location on the sequence: help QRGLKTVFDEAIRAVLCPPP V KKRKRKCLLL The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 189 Ras-related C3 botulinum toxin substrate 1
Motif 179 – 188 Polybasic region; required for nuclear import
Modified residue 189 – 189 Cysteine methyl ester
Lipidation 183 – 183 (Microbial infection) N6-palmitoyl lysine
Lipidation 184 – 184 (Microbial infection) N6-palmitoyl lysine
Lipidation 189 – 189 S-geranylgeranyl cysteine
Cross 166 – 166 Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Mutagenesis 166 – 166 K -> R. Loss of FBXL19-induced polyubiquitination.
Mutagenesis 183 – 183 K -> A. Slightly decreased palmitoylation by the V.cholerae toxin RtxA.
Mutagenesis 184 – 184 K -> A. Slightly decreased palmitoylation by the V.cholerae toxin RtxA.
Mutagenesis 186 – 186 K -> A. Decreased palmitoylation by the V.cholerae toxin RtxA.
Mutagenesis 188 – 188 K -> A. Decreased palmitoylation by the V.cholerae toxin RtxA.



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.