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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P01859: Variant p.Ser60Ala

Immunoglobulin heavy constant gamma 2
Gene: IGHG2
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Variant information Variant position: help 60 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LB/B The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change: help From Serine (S) to Alanine (A) at position 60 (S60A, p.Ser60Ala). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from small size and polar (S) to small size and hydrophobic (A) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Polymorphism: help There are several alleles. The sequence shown is that of IMGT allele IGHG2*06. Additional information on the polymorphism described.


Sequence information Variant position: help 60 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 395 The length of the canonical sequence.
Location on the sequence: help SWNSGALTSGVHTFPAVLQS S GLYSLSSVVTVPSSNFGTQT The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 1 – 395 Immunoglobulin heavy constant gamma 2
Topological domain 1 – 346 Extracellular
Domain 6 – 99 Ig-like 1
Region 1 – 98 CH1
Disulfide bond 27 – 83



Literature citations
The amino acid sequences of the three heavy chain constant region domains of a human IgG2 myeloma protein.
Connell G.E.; Parr D.M.; Hofmann T.;
Can. J. Biochem. 57:758-767(1979)
Cited for: PROTEIN SEQUENCE OF 1-85 AND 132-325; VARIANT ALA-60; The primary structure of a human IgG2 heavy chain: genetic, evolutionary, and functional implications.
Wang A.-C.; Tung E.; Fudenberg H.H.;
J. Immunol. 125:1048-1054(1980)
Cited for: PROTEIN SEQUENCE OF 1-325; VARIANT ALA-60;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.